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EC number: 221-259-8 | CAS number: 3048-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Comparable to guideline study. Well documented study which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative acute toxicity and primary irritancy of the ethylidene and vinyl isomers of norbornene.
- Author:
- Ballantyne B, Myers R and Klonne D.
- Year:
- 1 997
- Bibliographic source:
- J. Applied Toxicology 17, 211-221.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Method not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 5-vinylnorborn-2-ene
- EC Number:
- 221-259-8
- EC Name:
- 5-vinylnorborn-2-ene
- Cas Number:
- 3048-64-4
- Molecular formula:
- C9H12
- IUPAC Name:
- 5-ethenylbicyclo[2.2.1]hept-2-ene
- Reference substance name:
- 5-vinyl-2-norbornene
- IUPAC Name:
- 5-vinyl-2-norbornene
- Details on test material:
- - Test substance: 5-vinyl-2-norbornene (CAS 3048-64-4)
- Purity: >99%
- Source: Union Carbide Corporation, South Charleston, West Virginia
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Vapour produced by metered piston pump delivering liquid into a heated evaporator at 40-50C
- Exposure chamber volume: 1300litre
- Method of holding animals in test chamber:
- Source and rate of air: 250litre/min
TEST ATMOSPHERE
- Brief description of analytical method used: gas sampler and GC/FID every 5 minutes. Nominal concentrations based on mass volume consumed.
- Samples taken from breathing zone: no - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 1551, 2084, 2365, 2682, 3259 ppm.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?)
- Frequency of observations and weighing: daily. Weighted at 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 2 231 ppm
- 95% CL:
- 1 938 - 2 568
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 2 518 ppm
- 95% CL:
- 2 268 - 2 796
- Exp. duration:
- 4 h
- Mortality:
- Males: 0/5, 1/5, 3/5, 5/5, 4/5 at each dose. For females, none died up to 2365ppm, all died at 2682ppm and above.
- Clinical signs:
- other: At approximately the LC50 concentration, animals exhibited hind leg paralysis in 7/20 animals post exposure. Hypereactivity, tremors, and convulsions also reported.
- Body weight:
- Decreased body weight was seen at 2084ppm but not at 1581ppm.
- Gross pathology:
- No gross pathology was reported..
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 4-hr LC50 value indicates a moderate degree of vapor toxicity. At these high vapor concentration, signs are predominantly those of a central excitatory nature, particularly hypereactivity, tremors, and convulsions.
- Executive summary:
In a reliable study, Ballantyne et al (1997) published acute 4 -hr LC50 values of 2231 ppm (11.2 mg/l) (males) and 2518 ppm (12.6 mg/l) (females) for vinyl norbornene vapor in rats.
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