Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.011 mg/L
Assessment factor:
10

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.001 mg/L
Assessment factor:
100

STP

Hazard assessment conclusion:
no hazard identified

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
3.16 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.316 mg/kg sediment dw

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.624 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

With respect to environmental fate and pathways, 2-methylglutaric acid is readily biodegradable (63.9 % biodegradation after 28 days, fulfilling the 10 -day window criterion) and not potentially bioaccumulable based on a low log Kow value (< -1.3 at pH = 7). Acute ecotoxicity data are available on the three trophic levels (i.e. fish, daphnid, algae) and reveal that 2-methylglutaric acid does not exert any acute adverse effects at the highest concentration tested of 100 mg/L. The L/EC50 are thus superior to 100 mg/L in the three species. The study on algal growth inhibition reports EC10 and NOEC values that could be considered as indicative of chronic toxicity. These values are > 100 mg/L and >= 100 mg/L, respectively. Chronic toxicity test on fish similarly reported an absence of adverse effect up to and including the highest tested concentration; giving a NOEC >= 10 mg/L. Finally, adverse effects were reported during the chronic toxicity study on Daphnia magna with a NOEC = 0.11 mg/L based on reproduction. Considering the environmental fate and ecotoxicity data together leads to conclude that 2-methylglutaric acid does not need to be classified under DSD, but requires a classification in aquatic chronic toxicity category 3 (H412) under CLP.