Registration Dossier
Registration Dossier
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EC number: 224-518-3 | CAS number: 4394-85-8
Endpoint summary
Administrative data
Description of key information
Additional information
The most sensitive organisms regarding acute toxicity to 4-morpholinecarbaldehyde were Leuciscus idus (fish) and Daphnia magna (aquatic invertebrate) with LC/EC50s greater than 500 mg/L. The ErC50 for algae was determined to be 23880 mg/L (ErC10 = 17040 mg/L). Experimental data on long-term toxicity to fish and aquatic invertebrates are not available, however, based on the ACR approach the derived NOECs were greater than 1 mg/L.
In all of the available studies, the test item concentrations were not analytically verified but are assumed to be stable regarding the substance's properties: low volatility, high water solubility, not significantly bioaccumulative, adsorption not expected.
Short-term toxicity to fish:
BASF AG, 1984, Rep. no. 82/42, DIN 38412, Leuciscus idus, 96h LC50 > 500 mg/L.
With high probability acutely not harmful to fish.
Long-term toxicity to fish:
According to REACH Annex XI, chapter 3 (SUBSTANCE-TAILORED EXPOSURE-DRIVEN TESTING), testing in accordance with Sections 8.6 and 8.7 of Annex VIII and in accordance with Annex IX and Annex X may be omitted, based on the exposure scenario(s) developed in the Chemical Safety Report. For 4-morpholinecarbaldehyde there is a risk assessment available and submitted with the registration dossier, which includes all life cycle steps of the substance. This risk assessment demonstrates, taking into account the appropriate safety factors, the safe use of the substance throughout its entire life cycle. For none of the protection goals, the use of the substance creates an unacceptable risk. The resulting RCR determined for all compartments demonstrate no significant exposure in all scenarios of the manufacture and all identified uses as referred to in Annex VI section 3.5. with a maximum RCR of 0.04. Therefore, it is concluded that 4-morpholinecarbaldehyde does not pose a risk to the environment.
Short-term toxicity to aquatic invertebrates:
BASF AG, 1987, Rep. no. 1/1679/2/88, EC Dir. 79/831/EEC, Annex V, part C2, Daphnia magna, 48h EC50 > 500 mg/L.
With high probability acutely not harmful to aquatic invertebrates.
Long-term toxicity to aquatic invertebrates:
The chronic toxicity to aquatic invertebrates was investigated via the QSAR Toolbox v4.4 calculation model. The 21-d NOEC was determined to be 38 mg/L (BASF SE, 2021).
Toxicity to aquatic algae and plants:
BASF AG, 1990, Rep. no. 01/90/143, DIN 38412, part 9, Desmodesmus subspicatus, 72h ErC50 = 23880 mg/L, 72h ErC10 = 17040 mg/L.
With high probability acutely not harmful to aquatic algae.
Toxicity to microorganisms:
BASF AG, 198, Rep. no. 9/0553/87, DIN 38412, part 8, Pseudomonas putida, EC10 (17 h) > 2000 mg/L.
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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