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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
Deviations:
yes
Remarks:
deviation is conidered as uncritical
Principles of method if other than guideline:
Temperature in the limit test lay in the range of 21.7 - 22.5 °C instead of 18 - 22 °C. As the difference is only marginal and respiration rate of the activated sludge lay in the normal range, the deviation is considered as uncritical.
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
yes
Vehicle:
no
Test organisms (species):
activated sludge, domestic
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
3 h
Reference substance (positive control):
yes
Remarks:
3,5-Dichlorophenole
Duration:
3 h
Dose descriptor:
NOEC
Effect conc.:
1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
3 h
Dose descriptor:
other: EC20
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Conclusions:
NOEC = 1,000 mg/L
EC50 >> 1,000 mg/L
Executive summary:

In the limit test, the mean inhibition which was caused by the test item was 12 %. Therefore, no main study was performed and no exact 3h EC50 was determined. The value is stated > 1,000 mg/L". As inhibition of the treatment 1,000 mg/L lies below the recommended limit for variation within the controls, 1,000 mg/L can be stated as NOEC.

All validity criteria were met.

Description of key information

NOEC(3 h) = 1000 mg/L	
EC20(3 h) > 1000 mg/L		
EC50(3 h) > 1000 mg/L

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L
EC10 or NOEC for microorganisms:
1 000 mg/L

Additional information