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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
endocrine system modulation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: according to P. Sohoni and J.P. Sumpter (1998)
Principles of method if other than guideline:
The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Androgenic as weil as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
GLP compliance:
no
Type of method:
in vitro

Test material

Constituent 1
Reference substance name:
1-(2-Hydroxy-5-nonyl(branched)-phenyl)ethanone oxime
EC Number:
627-083-1
Cas Number:
244235-47-0
IUPAC Name:
1-(2-Hydroxy-5-nonyl(branched)-phenyl)ethanone oxime
Details on test material:
- Name of test material: C9 Ketoxim
- Physical state: Liquid, greygreen, clear
- Analytical purity: >90%
- Storage condition of test material: Room temperature

Test animals

Species:
other: yeast

Administration / exposure

Vehicle:
DMSO

Results and discussion

Details on results:
In this study, the test substance C9 Ketoxim showed no androgenic activity in comparison to dihydrotestosterone.
In this study, the test substance C9 Ketoxim showed clear antiandrogenic activity from about 10-6 mol/L onward in comparison to hydroxyflutamide.
No cytotoxicity was observed.

Applicant's summary and conclusion