Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: SNIF file released by ECHA
Title:
Unnamed
Year:
1987

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: OECD 474 (1986)
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
Olive oil
No. of animals per sex per dose:
Male : 525 mg/kg; number of animals : 5; sacrifice time : 16 hours
Male : 525 mg/kg; number of animals : 5; sacrifice time : 24 hours
Male : 525 mg/kg; number of animals : 5; sacrifice time : 48 hours
Male : 1050 mg/kg; number of animals : 5; sacrifice time : 16 hours
Male : 1050 mg/kg; number of animals : 5; sacrifice time : 24 hours
Male : 1050 mg/kg; number of animals : 5; sacrifice time : 48 hours
Male : 2100 mg/kg; number of animals : 5; sacrifice time : 16 hours
Male : 2100 mg/kg; number of animals : 5; sacrifice time : 24 hours
Male: 2100 mg/kg; number of animals : 5; sacrifice time : 48 hours
Female : 525 mg/kg; number of animals : 5; sacrifice time : 16 hours
Female : 525 mg/kg; number of animals : 5; sacrifice time : 24 hours
Female : 525 mg/kg; number of animals : 5; sacrifice time : 48 hours
Female : 1050 mg/kg; number of animals : 5; sacrifice time : 16 hours
Female : 1050 mg/kg; number of animals : 5; sacrifice time : 24 hours
Female : 1050 mg/kg; number of animals : 5; sacrifice time : 48 hours
Female : 2100 mg/kg; number of animals : 5; sacrifice time : 16 hours
Female : 2100 mg/kg; number of animals : 5; sacrifice time : 24 hours
Female : 2100 mg/kg; number of animals : 5; sacrifice time : 48 hours

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Vehicle controls valid:
not specified
Negative controls valid:
not specified
Positive controls valid:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
Ethylhexyltriazone : not classified as mutagenic.