Registration Dossier

Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: SNIF file released by ECHA
Title:
Unnamed
Year:
1987
Report Date:
1987

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: OECD 408 (1987)
GLP compliance:
yes
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: None
Details on oral exposure:
Method of administration : food
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
Test duration : 90 days
Frequency of treatment:
Dosing regime : 7 days/week

Results and discussion

Results of examinations

Details on results:
Clinical observations : No premature mortalities occurred. Clinically, laboratory-diagnostically and pathomorphologically, no substance related pathological changes could be observed.
Laboratory findings : Slight variations in the haematological and clinico-chemical parameters corresponded to the range of biological variaton in the species.
Effects in organs : Liver weight increases without histological correlates among treated female animals could not be interpreted as being substance related.

Effect levels

Dose descriptor:
NOEL
Effect level:
1 000 mg/kg bw/day (nominal)
Sex:
not specified
Basis for effect level:
other: original NCD unit is mg/kg/day

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Ethylhexyltriazone : not classified.