Registration Dossier
Registration Dossier
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EC number: 229-563-2 | CAS number: 6610-29-3
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: 4e: Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- MTSC was applied on either abraded or unbraded rabbit skin at doses of 3.75 and 15 mg/kg bw for 20 daily treatments.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylthiosemicarbazide
- EC Number:
- 229-563-2
- EC Name:
- 4-methylthiosemicarbazide
- Cas Number:
- 6610-29-3
- Molecular formula:
- C2H7N3S
- IUPAC Name:
- 1-amino-3-methylthiourea
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- not specified
- Details on exposure:
- Test substance was applied as a 5% aqueous solution.
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3.75 or 15 mg/kg
Basis:
- No. of animals per sex per dose:
- no data
- Details on study design:
- MTSC was applied on either abraded or unbraded rabbit skin
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Haematological findings:
- no effects observed
- Details on results:
- No clinicals findings, no haematological or biochemical parameters and no anatomo-pathological abnormalities were found.
Furthermore, no deaths occured during the study.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
