Registration Dossier
Registration Dossier
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EC number: 263-005-9 | CAS number: 61788-78-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 June, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Critical micelle concentration (CMC) method is used as an alternative to the water solubility.
- Reason / purpose for cross-reference:
- reference to other assay used for intermediate effect derivation
- Principles of method if other than guideline:
- For surface active substances the critical micelle concentration (CMC) method is used as an alternative to the water solubility. The critical micelle concentration (CMC) is determined by measuring the surface tension of test substance solutions at different test substance concentration. For surface active substances which form micelles in solution, the surface tension decreases with increasing concentration until the CMC is reached. At concentrations above the CMC, the surface tension remains constant. The CMC is determined from a plot of the surface tension versus the logarithm of the test substance concentration.
- GLP compliance:
- no
- Type of method:
- other: critical micelle concentration (CMC)
- Key result
- Water solubility:
- 0.1 g/L
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: critical micelle concentration (CMC)
- Conclusions:
- Under the study conditions, the water solubility (critical micelle concentration) of the test substance was determined to be 0.10 g/L or 100 mg/L at 25°C.
- Executive summary:
A study was conducted to determine the water solubility of the test substance, C16-18 TMAC (72.78% active) using the critical micelle concentration (CMC) method, which is recommended for surface active substances. Under the study conditions, the CMC of the test substance was determined to be 0.10 g/L at 25°C (Borjesson, 2012).
Reference
Description of key information
The water solubility of the test substance was determined using critical micelle concentration (CMC) method, which is recommended for surface active substances (Borjesson, 2012). Key value for chemical safety assessment
- Water solubility:
- 0.1 g/L
- at the temperature of:
- 25 °C
Additional information
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