Registration Dossier
Registration Dossier
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EC number: 255-911-8 | CAS number: 42613-21-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Study period:
- 20 Jul 1984-15 Oct 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Objective of study:
- distribution
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 413
- GLP compliance:
- yes
Test material
- Reference substance name:
- 112945-52-5
- EC Number:
- 601-216-3
- Cas Number:
- 112945-52-5
- IUPAC Name:
- 112945-52-5
- Reference substance name:
- Silica, amorphous, fumed
- IUPAC Name:
- Silica, amorphous, fumed
- Details on test material:
- - Name of test material (as cited in study report): Aerosil 200
- Analytical purity: > 99.8%
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- 6 h/day, 5 days/week for 13 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.3, 5.9 or 31 mg/m3 (analytical concentration)
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- yes
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- Silica could be detected in lungs only in relatively small amounts at the end of the exposure period, on the average 0.2 mg in all animals of the 30-mg groups. Only one male exposed to 30 mg/m3 showed a small amount of silica in the regional lymph node. During the post-exposure observation period, no silica could be recovered from any animal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
