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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1993
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
O-acetylsalicylic acid
EC Number:
200-064-1
EC Name:
O-acetylsalicylic acid
Cas Number:
50-78-2
Molecular formula:
C9H8O4
IUPAC Name:
2-acetoxybenzoic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
0.1 mL of TS
TS 70% in 30% NaHCO3

Test animals / tissue source

Species:
rabbit
Strain:
Flemish Giant

Test system

Vehicle:
other: 30% NaHCO3
Controls:
not required
Duration of treatment / exposure:
4 hours
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 7 days
Score:
0
Max. score:
0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Acetyl salicylic acid (ASA) is not irritating to the rabbit eye
Executive summary:

ASA tested according to GL 405 is not irritant to the rabbit eye.