Registration Dossier
Registration Dossier
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EC number: 700-230-8 | CAS number: 3160-86-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No reproductive toxicity data are available for the PA6T salt. Data for terephthalic acid suggests possible effect on foetal development, but this was considered to be secondary to severe maternal toxicity. Also, some postnatal effects in the offspring were considered to be due to bladder calculi formation from ingestion of terephthalic acid and its precipitation in the bladder. While some effects on offspring were also seen with HMDA, the effects were confined to decreases in body weight and/or litter size, but this occurred at maternally toxic levels and therefore is considered secondary to maternal toxicity. Collectively, these data indicate that PA6T salt should not be considered at toxic to the reproductive system.
References:
OECD SIDS (2004). OECD SIDS Dossier for Adipic Acid (CAS 124-04-9) (http://www.inchem.org/documents/sids/sids/124049.pdf).
OECD SIDS (2001). OECD SIDS Dossier for Terephthalic Acid (CAS 100-21-0) (http://www.chem.unep.ch/irptc/sids/OECDSIDS/100-21-0.pdf).
OECD SIDS (nd). OECD SIDS Dossier for Hexamethylenediamine (CAS 124-09-4) (http://www.inchem.org/documents/sids/sids/124094.pdf).
OECD SIDS (2003). OECD SIDS for Adipic Acid, Compound with Hexane-1,6-diamine (1:1) (CAS 3323-53-3) (http://www.chem.unep.ch/irptc/sids/OECDSIDS/3323533.pdf).
BASF (2014). Material Safety Data Sheet, AH-salt solution (http://www.plasticsportal.net/wa/EU/Catalog/ePlastics/doc4/BASF/PRD/30214804/.pdf?title=&asset_type=msds/pdf&language=EN&validArea=REG_EU&urn=urn:documentum:ProductBase_EU:09007af88001a52c.pdf).
Effects on developmental toxicity
Additional information
No developmental toxicity data are available for the PA6T salt [1,4-benzenedioic acid, compound with hexane-1,6-diamine (1:1)]. While some effects (i.e., foetal variations) have been observed for HMDA, effects occurred at maternally toxic levels and therefore are considered secondary to maternal toxicity. While some rib anomalies were seen in an inhalation study with terephthalic acid, the effect was only significant when all types of rib abnormalities were pooled. Additionally, the anomalies were not considered to be indicative of specific developmental toxicity as they represent common variations, were not increased in a dose-related manner, occurred within the range of laboratory historical controls and occurred without the presence of other manifestations of developmental toxicity. Collectively, this data indicates that PA6T salt should not be considered a developmental toxin.
References:
OECD SIDS (2004). OECD SIDS Dossier for Adipic Acid (CAS 124-04-9) (http://www.inchem.org/documents/sids/sids/124049.pdf).
OECD SIDS (2001). OECD SIDS Dossier for Terephthalic Acid (CAS 100-21-0) (http://www.chem.unep.ch/irptc/sids/OECDSIDS/100-21-0.pdf).
OECD SIDS (nd). OECD SIDS Dossier for Hexamethylenediamine (CAS 124-09-4) (http://www.inchem.org/documents/sids/sids/124094.pdf).
OECD SIDS (2003). OECD SIDS for Adipic Acid, Compound with Hexane-1,6-diamine (1:1) (CAS 3323-53-3) (http://www.chem.unep.ch/irptc/sids/OECDSIDS/3323533.pdf).
BASF (2014). Material Safety Data Sheet, AH-salt solution (http://www.plasticsportal.net/wa/EU/Catalog/ePlastics/doc4/BASF/PRD/30214804/.pdf?title=&asset_type=msds/pdf&language=EN&validArea=REG_EU&urn=urn:documentum:ProductBase_EU:09007af88001a52c.pdf).
Justification for classification or non-classification
Based on data from component chemicals and similar salts the test substance is not expected to be a developmental or reproductive toxin. Therefore the test substance is not classified for developmental or reproductive toxicity according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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