Registration Dossier
Registration Dossier
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EC number: 700-230-8 | CAS number: 3160-86-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
No repeated dose toxicity data are available for the PA6T salt [1,4-benzenedioic acid, compound with hexane-1,6-diamine (1:1)]. Repeated dose effects observed with component chemicals have involved either non-specific body weight changes or specific organ pathology (e.g., kidney or bladder), but occurring at doses much greater than the reporting threshold (i.e., 100 mg/kg/day for oral exposure). In addition, the PA66 salt [adipic acid, compound with hexane-1,6-diamine (1:1); CAS# 3323-53-3; EC# 222-037-3] is not classified for repeated exposure effects. Collectively, these date indicate that PA6T salt should not be classified for repeated exposure effects.
References:
OECD SIDS (2004). OECD SIDS Dossier for Adipic Acid (CAS 124-04-9) (http://www.inchem.org/documents/sids/sids/124049.pdf).
OECD SIDS (2001). OECD SIDS Dossier for Terephthalic Acid (CAS 100-21-0) (http://www.chem.unep.ch/irptc/sids/OECDSIDS/100-21-0.pdf).
OECD SIDS (nd). OECD SIDS Dossier for Hexamethylenediamine (CAS 124-09-4) (http://www.inchem.org/documents/sids/sids/124094.pdf).
OECD SIDS (2003). OECD SIDS for Adipic Acid, Compound with Hexane-1,6-diamine (1:1) (CAS 3323-53-3) (http://www.chem.unep.ch/irptc/sids/OECDSIDS/3323533.pdf).
BASF (2014). Material Safety Data Sheet, AH-salt solution (http://www.plasticsportal.net/wa/EU/Catalog/ePlastics/doc4/BASF/PRD/30214804/.pdf?title=&asset_type=msds/pdf&language=EN&validArea=REG_EU&urn=urn:documentum:ProductBase_EU:09007af88001a52c.pdf).
Justification for classification or non-classification
Based on data from component chemicals and similar salts, no effects at the threshold or lower are expected with the test substance. Therefore the test substance is not classified for repeated dose toxicity according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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