α,α,α-trifluoro-o-toluoyl chloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Limited methodological detail is provided; however the study is considered to be sufficiently reliable for the purposes of classification and labelling.

Data source

Reference

Reference Type:

publication

Title:

The Toxicity and Structure of Various Aromatic Fluorides

Author:

Tai,T., Yamashita, M., Takeda, M., and Naito, H.

Year:

1986

Bibliographic source:

Burgetaheir, A.W (ed.) Fluoride Official Quarterly Journal; Volume 19 no. 3; The International Society for Fluoride Research, Michigan, USA, 117-121

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

Principles of method if other than guideline:

2-trifluoromethylbenzoyl chloride was administered via microcylinder through a stomach tube. Syptoms were observed for 8 hours and deaths, symptoms and body weight were noted for 7 days. The median lethal dose (LD50) was calculated by the method of Litchfield and Wilcoxon as the standard of mortality to 72 hours following the administration.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-trifluoromethylbenzoyl chloride

IUPAC Name:

2-trifluoromethylbenzoyl chloride

Test material form:

other: liquid (oil)

Details on test material:

- Name of test material (as cited in study report):2-trifluoromethylbenzoyl chloride
- Physical state: liquid
- Analytical purity: >99% using gas chromatography

Test animals

Species:

rat

Strain:

Wistar

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: 7 weeks old
- Acclimation period: 1 week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/- 1
- Humidity (%): 55 +/- 5
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 1.5 ml/g body weight

Doses:

0.5-1.5 ml/g body weight

No. of animals per sex per dose:

No data

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: once daily
- Necropsy of survivors performed: no

Statistics:

The median lethal dose (LD50) was calculated by the method of Litchfield and Wilcoxon

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

8 200 mg/kg bw

Based on:

test mat.

95% CL:

7 000 - 9 500

Mortality:

No data

Clinical signs:

other: Decreased movement and 'weakness' were observed and resolvd within 3 days.

Gross pathology:

No data

Other findings:

No data

Any other information on results incl. tables

No data

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 for 2-trifluoromethylbenzoyl chloride is 8200 mg/kg bw therefore it is not classified according to Regulation (EC) No 1272/2008

Executive summary:

The results of this study indicate low acute oral toxicity of 2-trifluoromethylbenzoyl chloride in the rat. Based on an LD50 value of 8200 mg/kg bw, the substance does not require classification according to the CLP Regulation.