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EC number: 200-493-4 | CAS number: 60-93-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study is not done according to OECD guideline, but it is a well documented study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenicity studies with x-ray-contrast Media, analgesics, antipyretics, antirheumatics and some other pharmaceutical drugs in Bacterial, Drosphila and Mammalian test systems.
- Author:
- King, M. T., Beikirch, H., Eckhardt, K., Gocke, E. and Wild, D.
- Year:
- 1 979
- Bibliographic source:
- Mutat Res. 66(1):33-43
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test was performed according to the method of Schmid, 1976 with male and female NMRI mice, weighing about 30 g. Usually, 4 mice were used for each of 3 doses and controls. Doses were selected on the basis of previous toxicity experiments ranging from non-toxic to approximate lethal doses. Test compound was administered either i.p. or by gavage as solutions. They were given twice at 24 h apart; 6 h after the second dose the animals were killed by cervical dislocation. Bone-marrow smears were then prepared and stained with May-Gruenwald and Giemsa stains. A total of 1000 polychromatic erythrocytes were analyzed for each animal. For calculating the significance of results the tables of Kastenbaum and Bowman (Kastenbaum et al., 1976) were used. For positive control experiments various mutagens were administered, and representative data have been reported (Wild, 1978).
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Quinine dihydrochloride
- EC Number:
- 200-493-4
- EC Name:
- Quinine dihydrochloride
- Cas Number:
- 60-93-5
- Molecular formula:
- C20H24N2O2.2ClH
- IUPAC Name:
- 6'-methoxycinchonan-9-ol dihydrochloride
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Quinine dihydrochloride
- other: obtained from EGA-Chemie GmbH and Co. KG, Stemhelm/Albuch, Germany
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 30 g
Administration / exposure
- Route of administration:
- other: intraperitoneal application and oral application (gavage)
- Duration of treatment / exposure:
- 6 h after second dose
- Frequency of treatment:
- twice at 24 h apart
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5 mmoles/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4 mice (female and male)
- Control animals:
- yes
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not specified
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
The result of the micronucleus test in NMRI mice was negative after intraperitoneal and oral application. Thus, quinine dihydrochloride can be considered not genotoxic. - Executive summary:
In the study published by King et al., 1979 the genotoxicity of quinine dihydrochloride was determined with the mirconucleus test in NMRI mice. Quinine hydrochloride was given twice at 24 h apart (0.5 mmoles/kg). The micronucleus test in NMRI mice were negative. Thus, Quinine dihydrochloride can be considered as not genotoxic.
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