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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
Rats were fasted overnight. Test article was administered neat via oral gavage
Doses:
1250, 2500, 5000 mg/kg
No. of animals per sex per dose:
five (5)
Control animals:
no
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
no deaths were observed in any treatment group
Clinical signs:
At most, slightly toxic orally. No compound-related effects were observed at gross pathology examination of the high-dose group of animals.
Body weight:
136-149 g (male); 143-160 (female)
Gross pathology:
No compound-related effects were observed at gross pathology examination of the high-dose group of animals.
Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
No compound-related effects were observed at gross pathology examination of the high-dose group of animals. The compound (m-diisopropylbenzene) was considered to be slightly toxic following oral administration.
Executive summary:

No compound-related effects were observed at gross pathology examination of the high-dose group of animals. The compound (m-diisopropylbenzene) was considered to be slightly toxic following oral administration.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study was conducted in a GLP facility to the standards of the time
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no
Species:
guinea pig
Strain:
Hartley
Sex:
male/female
Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
2 weeks
Doses:
20 mL/kg
No. of animals per sex per dose:
five (5)
Control animals:
no
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 20 mL/kg bw
Mortality:
no mortality was observed 2 weeks following test material administration
Clinical signs:
no evidence of percutaneous absorption
Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
At most, m-diisopropylbenzene is only slightly toxic by the dermal route. There was no evidence of percutaneous absorption.
Executive summary:

At most, m-diisopropylbenzene is only slightly toxic by the dermal route. There was no evidence of percutaneous absorption.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
20 000 mg/kg bw

Additional information

Justification for selection of acute toxicity – oral endpoint
No compound-related effects were observed at gross pathology examination of the high-dose group of animals. The compound (m-diisopropylbenzene) was considered to be only slightly toxic following oral administration with an acute oral LD50 value of greater than 5000 mg/kg body weight.

Justification for selection of acute toxicity – inhalation endpoint
Inhalation is not considered to be a relevant route of potential human exposure

Justification for selection of acute toxicity – dermal endpoint
At most, m-diisopropylbenzene is only slightly toxic by the dermal route. There was no evidence of percutaneous absorption. The acute oral LD50 value was determined to be greater than 20 mL/kg body weight.

Justification for classification or non-classification

Based on a weight-of-the-evidence assessment, m-diisopropylbenzene is not classified for acute toxicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 and UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS).