Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-015-6 | CAS number: 505-65-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 420 mg/L
Additional information
One toxicity test on freshwater fish is available. This static test was carried out according to German national standards (DIN 38412). The determined LC50 for Leuciscus idus ranges between 2200 and 4600 mg/L [BASF AG, 1987]. The NOAEC was estimated to be 1000 mg/L.
The study design and the lack of analytical verification of exposure concentrations limit the adequacy of the study to address the acute toxicity of the substance, which has potential to evaporate from the test system due to its physical-chemical properties
However, based on its chemical structure, 1,3-dioxepane is expected to exert acute aquatic toxicity through a narcotic mode of action (narcosis or baseline toxicity) and therefore the endpoint can be adequately estimated from its structure. Estimations of short-term toxicity to fish conducted with two valid QSAR methods confirm the very low toxicity of 1,3 -dioxepane to fish and support the result from the available experimental study.
A LC50 (96 h) of 1420 mg/L (estimated by OECD Toolbox 4.1) is taken for the chemical safety assessment.
In conclusion, taking together the available experimental data and the QSAR predictions and using a weight-of-evidence approach, a LC50 (96 h) of > 1000 mg/l can be estimated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
