Registration Dossier
Registration Dossier
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EC number: 200-076-7 | CAS number: 51-03-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1995
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
- Type of study / information:
- Review of toxicology
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
- EC Number:
- 200-076-7
- EC Name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
- Cas Number:
- 51-03-6
- Molecular formula:
- C19H30O5
- IUPAC Name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Piperonyl butoxide has a low order of acute and chronic toxicity, is not genotoxic, teratogenic, toxic to the reproductive system or oncogenic in three mouse and two rat oncogenicity studies. The liver is the principal target organ and the main toxicological findings are a consequence of hepatotoxicity at very high doses.
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