Registration Dossier
Registration Dossier
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EC number: 203-965-8 | CAS number: 112-38-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies of the acute and chronic toxicity of undecylenic acid
- Author:
- Newell GW et al.
- Year:
- 1 949
- Bibliographic source:
- J. Invest. Dermatol. 1949 ; 13 : 145-14
Materials and methods
Test material
- Reference substance name:
- Undec-10-enoic acid
- EC Number:
- 203-965-8
- EC Name:
- Undec-10-enoic acid
- Cas Number:
- 112-38-9
- Molecular formula:
- C11H20O2
- IUPAC Name:
- undec-10-enoic acid
- Details on test material:
- no data on source and purity
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Carworth CF1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data on source and age;
weight at sudy initiation: 18- 22g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: sesame oil
- Doses:
- 11, 16, 20, 24 and 36 mg
- No. of animals per sex per dose:
- 30
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 953 - 967 mg/kg bw
- Mortality:
- see table 1
- Clinical signs:
- no data
- Gross pathology:
- No obvious target organ
Any other information on results incl. tables
Table 1: Number of animals dead [and with evident toxicity] [and time range within which mortality occurred]
Dose |
Mortality (# dead/total) |
Time range of deaths (hours) |
Number with evident toxicity (#/total) |
||||
Male |
Female |
Combined |
Male |
Female |
Combined |
||
Control |
|
|
|
|
|
|
|
11 |
|
|
1/6 |
|
|
|
|
16 |
|
|
0/6 |
|
|
|
|
20 |
|
|
5/6 |
|
|
|
|
24 |
|
|
6/6 |
|
|
|
|
| 36 | 6/6 | ||||||
Applicant's summary and conclusion
- Conclusions:
- The calculated LD50 was 960 mg/kg bw for intraperitoneal administration.
- Executive summary:
The acute toxicologic potential of Undecylenic Acid was evaluated in the mouse in a procedure similar to OECD guideline 401. The test substance was applied intraperitoneally. The calculated LD50 was 960 mg/kg bw for intraperitoneal administration.
First results of an ongoing chronic toxicity are reported, but the study was not finished at the timepoint of reporting.
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