Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1966

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Substance name: 1-Methylimidazol (flüssig)
Substance number: XVI/41

Test animals

Species:
mouse
Strain:
other: Klsolegg-
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
The test substance was given as a 4 to 20% aqueous solution.
Doses:
200, 350, 400, 500, 640, 800 and 1600 mm3/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 447 mg/kg bw
Based on:
test mat.
Remarks on result:
other: (original value is 430 mm3/kg)
Mortality:
200 mm3/kg: no deaths after 7 days
320 mm3/kg: 2/10 animalses after 7 days
400 mm3/kg: 3/10 animals after 7 days
500 mm3/kg and up: all animals died after 7 days
Clinical signs:
Tonic cramps
Gross pathology:
No abnormal observations

Applicant's summary and conclusion