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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Low attainable concentration due to the low vapour pressure, when the test substance is evaporated at 20°C, which is below cut off values for classification / any limit concentration.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1966

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
BASF-test: Test was performed in principle as described in OECD Guideline 403. The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20°C). 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder for 8 h. The documentation of clinical signs was performed over a period of 7 days. In order to verify the results, the test was repeated once. Calculatted saturated vapour concentration for 1-methylimidazole: 0.0412*MW*VP = 0.0412 * 82.1038 g/mol * 0.3514 hPa = 1.2 mg/L)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Substance name: 1-Methylimidazol (flüssig)
Substance number: XVI/41

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
saturated vapour at 20 ºC (calculated saturated vapour concentration: 1.2 mg/L)
No. of animals per sex per dose:
3
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: days 1 and 7
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
other: saturated vapour at 20 ºC (calculated saturated vapour concentration: 1.2 mg/L)
Based on:
test mat.
Exp. duration:
8 h
Mortality:
None of the animals died.
Clinical signs:
Signs of escape behaviour and distinct irritation of mucous membranes.
Body weight:
Normal body weight growth.
Gross pathology:
No effects.

Applicant's summary and conclusion

Interpretation of results:
other: The inhalation of a saturated vapour-air-mixture represents an unlikely acute hazard.