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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not specified
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken at 0, 96 h and 24 h, 48 h, 72 h (before and after test solution renewal)
- Vehicle:
- yes
- Remarks:
- ultrapure water
- Test organisms (species):
- other: Gobiocypris rarus (rare minnow)
- Details on test organisms:
- TEST ORGANISM
- Common name: rare minnow
- Source: bred and cultured in the laboratory
- Length at study initiation (length definition, mean, range and SD): 2.0-4.0 cm
ACCLIMATION
- Acclimation period: 7 day
- Acclimation conditions (same as test or not): same
- Type and amount of food during acclimation: feeding until 24 h before test
- Health during acclimation (any mortality observed): no abnormalities noted
FEEDING DURING TEST : no - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 10-250 mg CaCO3/L
- Test temperature:
- 21-25 °C
- pH:
- 6.0 - 8.5
- Dissolved oxygen:
- >80% of air saturation value
- Nominal and measured concentrations:
- Nominal: 10 mg/L
Measured: 92.81 - 129.44 µg/L - Reference substance (positive control):
- not required
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 43.6 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Details on results:
- - Behavioural abnormalities:
- Observations on body length and weight: no effects
- Other biological observations: none
- Mortality of control: no effects
- Other adverse effects control: no effects
- Abnormal responses:no effects
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no effects
- Effect concentrations exceeding solubility of substance in test medium: no - Validity criteria fulfilled:
- yes
- Remarks:
- mortality of controls < 10% (0%), dissolved oxygen >60% (66.9-88-2%)
- Conclusions:
- The 96-h LC50 of Di-PETMP is greater than 10 mg/L (nominal), the highest concentration tested.
- Executive summary:
The acute toxicity of the test item Di-PETMP to rare minnow (Gobiocypris rarus) was determined by a semi-static test according to OECD TG 203 . Based on the result of the preliminary test, a
limit test was performed with a nominal concentration of 10mg/L of the test item (Solubility of Di-PETMP in water: </= 3.7 mg/L). A blank control was carried out at the same time. The test duration was 96h and the frequency of renewal in the limit test was every 24h.
Seven test organisms were used for test concentration and control, respectively. No replicate was used. During the test, the mortality and abnormal behavior of the test
organism were recorded at 3h, 24h, 48h, 72h, 96h and the 96h-LCs, was determined.
Water quality parameters of test solution including temperature, dissolved oxygen and pH value were measured during the test duration. The test concentrations of test solutions were analyzed by LC-MS/MS.There were no mortalities or abnormalities observed in fish of the control group and the treatment group during the test.
Concentration analysis result of samples showed that, for newly prepared saturated test solution with nominal concentration of 10mg/L, the averaged analyzed concentration were 92.81 µg/L, 94.85 µg/L, 104.36 mg/L, 129.44 µg/L at time point of 0h, 24h, 48h and 72h (new solution ), respectively; After 24 hour of exposure, the analyzed concentrations at time point of 24h, 48h, 72h and 96h (old solution ) were all less than the limit of quantification (LOQ,50m g/L). During the test, the analyzed concentrations of Di-PETMP were not maintained in the initial concentration of 80%-120% in the exposure system because of the inevitable oxidation effect.However, effect levels based on mean measured concentrations don't represent the real environmental conditions because the test substance is rapidly oxidized by the oxygen content in the aqueous phase. Therefore, nominal values are used for hazard assessment.
Reference
Description of key information
The 96-h LC50 of Di-PETMP is greater than 10 mg/L(nominal), the highest concentration tested.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 10 mg/L
Additional information
The acute toxicity of the test item Di-PETMP to rare minnow (Gobiocypris rarus) was determined by a semi-static test according to OECD TG 203 . Based on the result of the preliminary test, a
limit test was performed with a nominal concentration of 10mg/L of the test item (Solubility of Di-PETMP in water: </= 3.7 mg/L). A blank control was carried out at the same time. The test duration was 96h and the frequency of renewal in the limit test was every 24h.
Seven test organisms were used for test concentration and control, respectively. No replicate was used. During the test, the mortality and abnormal behavior of the test
organism were recorded at 3h, 24h, 48h, 72h, 96h and the 96h-LCs, was determined.
Water quality parameters of test solution including temperature, dissolved oxygen and pH value were measured during the test duration. The test concentrations of test solutions were analyzed by LC-MS/MS.
There were no mortalities or abnormalities observed in fish of the control group and the treatment group during the test.
Concentration analysis result of samples showed that, for newly prepared saturated test solution with nominal concentration of 10mg/L, the averaged analyzed concentration were 92.81 µg/L, 94.85 µg/L, 104.36 mg/L, 129.44 µg/L at time point of 0h, 24h, 48h and 72h (new solution ), respectively; After 24 hour of exposure, the analyzed concentrations at time point of 24h, 48h, 72h and 96h (old solution ) were all less than the limit of quantification (LOQ,50m g/L). During the test, the analyzed concentrations of Di-PETMP were not maintained in the initial concentration of 80%-120% in the exposure system because of the inevitable oxidation effect.
However, effect levels based on mean measured concentrations don't represent the real environmental conditions because the test substance is rapidly oxidized by the oxygen content in the aqueous phase. Therefore, nominal values are used for hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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