Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-574-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Remarks:
- chronic exposure
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- 1. SOFTWARE: OECD QSAR TOOLBOX
2. MODEL (incl. version number): ECOSAR v1.1 Class-specific Estimations
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: O=C(OCCCCC[CC]CC]CCCCCCC)C(O)C
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: Fish - Chronic Value (ChV) = 10^([log (LOEC x NOEC)]/2)
- Class Specific LogKow Cut-Offs: If the log Kow of the chemical is greater than the endpoint specific cut-offs presented below, then no effects at saturation are expected for those endpoints.
Esters: Maximum LogKow: 8.0 (ChV)
Baseline Toxicity SAR Limitations: Maximum LogKow: 8.0 (ChV) - Principles of method if other than guideline:
- Calculation of the long-term effect concentration of a mixture based on individual values for the components assuming a similar mode of action.
- GLP compliance:
- no
- Analytical monitoring:
- not required
- Test organisms (species):
- not specified
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Remarks on exposure duration:
- ChV is a chronic value with undefined duration.
- Hardness:
- approximately 150 mg/L CaCO3, r
- Test temperature:
- abient
- pH:
- 7
- Dissolved oxygen:
- 100%
- Salinity:
- not applicable
- Conductivity:
- not specified
- Details on test conditions:
- The total organic carbon content should not exceed 2 mg/L
- Key result
- Dose descriptor:
- other: ChV
- Effect conc.:
- 0.01
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: sub-lethal effects
- Remarks on result:
- ChV (chronic value, QSAR)
Reference
Estimation of the chronic value of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters for fish:
Calculated based on QSAR values for Ester Toxicity:
Lactate | ChV | 1/ChV | f | f/ChV |
Dodecyl lactate | 0.037 | 27.0 | 0.60 | 16.22 |
Tetradecyllactate | 0.009 | 111 | 0.30 | 33.33 |
Hexadecyllactate | 0.002 | 500 | 0.10 | 50.0 |
Σf/ChV | 99.55 | |||
ChV of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters |
0.01 |
f= estimated average fraction of chemical in mixtur
Description of key information
Chronic value (ChV) calculated based on QSAR estimated individual ChV values for the C12, C14 and C16 lactates being the main constituents of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.01
Additional information
Estimation of the chronic value of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters for fish:
Calculated based on QSAR values for Ester Toxicity:
Lactate | ChV | 1/ChV | f | f/ChV |
Dodecyl lactate | 0.037 | 27.0 | 0.60 | 16.22 |
Tetradecyllactate | 0.009 | 111 | 0.30 | 33.33 |
Hexadecyllactate | 0.002 | 500 | 0.10 | 50.0 |
Σf/ChV | 99.55 | |||
ChV ofPropanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters |
0.01 |
f= estimated average fraction of chemical in mixtur
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)