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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 December 2011 to 09 March 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Version / remarks:
- (1981)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7370 (Dissociation constants in water)
- Version / remarks:
- (1996)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Identification FAT 40854/A TE
Description Reddish-brown powder (determined at NOTOX)
Batch TZ 5719 / BOP 02-11
Content 46.2% (4 main constituants)
Test substance storage At room temperature in the dark
Stability under storage conditions Stable
Expiry date 01 April 2016 - Dissociating properties:
- no
- Conclusions:
- No accurate pKa value of the test substance could be determined (OECD 112: titration method).
- Executive summary:
The dissociation constant of FAT 40854/A TE was determined according to OECD 112, EPA OPPTS 830.7370 and GLP.
With both test samples of the preliminary test two equivalence points were observed. With a titration run on a corresponding blank it was demonstrated that one of the equivalence points was related to the background of HCl.
Although an equivalence point of the test substance was found, the value was very close to the equivalence point of HCl and fell in its background. Therefore it was concluded that the main study could not be adequately performed and no accurate pKa value of the test substance could be determined.
Reference
Description of key information
No accurate pKa value of the test substance could be determined.
Key value for chemical safety assessment
Additional information
The dissociation constant of FAT 40854/A TE was determined according to OECD 112, EPA OPPTS 830.7370 and GLP.
With both test samples of the preliminary test two equivalence points were observed. With a titration run on a corresponding blank it was demonstrated that one of the equivalence points was related to the background of HCl.
Although an equivalence point of the test substance was found, the value was very close to the equivalence point of HCl and fell in its background. Therefore it was concluded that the main study could not be adequately performed and no accurate pKa value of the test substance could be determined.
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