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EC number: 935-847-3 | CAS number: 1369773-39-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan - July 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- The concentration of the test item in the test samples was determined immediately after preparation (t=0) and after 2.4 hours and 5 days. The samples taken at t=2.4 hours and t=5 days were cooled to room temperature using running tap water. Analysis was performed on subsamples of 650 µL. The samples were diluted with 350 µL of acetonitrile and analyzed.
Blank buffer solutions containing a similar content of blank spiking solution were treated similarly as the test samples and analyzed at t=0.
The pH of each of the test solutions (except for the blanks) was determined at each sampling time. - Buffers:
- Acetate buffer pH 4, 0.1 M
Solution of 16.7% 0.1 M sodium acetate in water and 83.3% 0.1 M acetic acid in water. Buffer contained 0.0009% (w/v) sodium azide.
Phosphate buffer pH 7, 0.1 M
Solution of 0.1 M potassium di-hydrogenphosphate in water adjusted to pH 7 using 10N sodium hydroxide. Buffer contained 0.0009% (w/v) sodium azide.
Borate buffer pH 9, 0.1 M
Solution of 0.1 M boric acid in water and 0.01 M potassium chloride in water adjusted to pH 9 using 10N sodium hydroxide. Buffer contained 0.0009% (w/v) sodium azide. - Estimation method (if used):
- The buffer solutions were filter-sterilised through a 0.2 µm FP 30/0.2 CA-S filter (Whatman, Dassel, Germany) and transferred into a sterile vessel. To exclude oxygen, nitrogen gas was purged through the solution for 5 minutes. The test item was spiked to the solutions at a target concentration of 2 mg/L using a spiking solution in dimethyl sulfoxide. For each sampling time, duplicate sterile vessels under vacuum were filled with 6 mL test solution and placed in the dark in a temperature controlled environment at 49.9°C ± 0.2°C. The spiking volume was < 1% of the sample volume. Nominal concentrations were not corrected for the spiking volume.
- Details on test conditions:
- Test samples were prepared and treated similarly as during the preliminary test. The concentrations of the test item were determined immediately after preparation (t=0) and at
several sampling points after t=0.
Blank buffer solutions were treated similarly as the test samples and analyzed at t=0.
The pH of each of the test solutions (except for the blanks) was determined at least at the beginning and at the end of the test.
Test Conditions Main Study
pH code Temperature I Temperature II Temperature III
pH 4 19.9°C ± 0.2°C 49.9°C ± 0.5°C 59.7°C ± 0.6°C
pH 7 19.9°C ± 0.2°C 50.0°C ± 0.4°C 59.7°C ± 0.7°C
pH 9 19.9°C ± 0.2°C 50.0°C ± 0.4°C 59.8°C ± 0.4°C - Duration:
- 795.07 h
- pH:
- 4
- Temp.:
- 20 °C
- Initial conc. measured:
- >= 1.93 - <= 1.96 mg/L
- Duration:
- 792.77 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 1.93 - <= 1.98 mg/L
- Duration:
- 769.78 h
- pH:
- 4
- Temp.:
- 60 °C
- Initial conc. measured:
- >= 1.95 - <= 1.97 mg/L
- Duration:
- 794.52 h
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- >= 2 - <= 2.01 mg/L
- Duration:
- 792.25 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 2 - <= 2.01 mg/L
- Duration:
- 840.93 h
- pH:
- 7
- Temp.:
- 60 °C
- Initial conc. measured:
- >= 2.01 - <= 2.02 mg/L
- Duration:
- 793.32 h
- pH:
- 9
- Temp.:
- 20 °C
- Initial conc. measured:
- >= 1.99 - <= 2.01 mg/L
- Duration:
- 409.97 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 2.01 - <= 2.03 mg/L
- Duration:
- 167.82 h
- pH:
- 9
- Temp.:
- 60 °C
- Initial conc. measured:
- 2.01 mg/L
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- yes
- Remarks:
- Blank buffer solutions containing a similar content of blank spiking solution were treated similarly as the test samples and analyzed at t=0.
- Statistical methods:
- For testing of pseudo-first order kinetics the mean logarithms of the relative concentrations between 10% and 90% were plotted against time. At all temperatures linear relationships were obtained.
The half-life times of the test item were determined according to the model for pseudo-first order reactions. All logarithms of the relative concentrations were correlated with time using linear regression analysis. - Preliminary study:
- At pH 4, pH 7 and pH 9, a degree of hydrolysis of = 10% was observed after 5 days.
- Test performance:
- Test samples were prepared and treated similarly as during the preliminary test. The concentrations of the test item were determined immediately after preparation (t=0) and at several sampling points after t=0.
Blank buffer solutions were treated similarly as the test samples and analyzed at t=0. The pH of each of the test solutions (except for the blanks) was determined at least at the beginning and at the end of the test. - Transformation products:
- no
- % Recovery:
- 97
- pH:
- 4
- Temp.:
- 20 °C
- Duration:
- 795.07 h
- % Recovery:
- 98
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 792.77 h
- % Recovery:
- 98
- pH:
- 4
- Temp.:
- 60 °C
- Duration:
- 769.78 h
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 20 °C
- Duration:
- 792.25 h
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 60 °C
- Duration:
- 840.93 h
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 792.25 h
- Key result
- pH:
- 4
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 1 210 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 87 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 4
- Temp.:
- 60 °C
- Hydrolysis rate constant:
- 1.06 h-1
- DT50:
- 27 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 6 641 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 290 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 7
- Temp.:
- 60 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 95 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 9
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 208 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.006 h-1
- DT50:
- 4.9 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 9
- Temp.:
- 60 °C
- Hydrolysis rate constant:
- 0.015 h-1
- DT50:
- 47 h
- Type:
- (pseudo-)first order (= half-life)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The half-life times of the test item were as follows:
pH 4 pH 7 pH 9
Temperature t½ t½ t½
[°C]
20 1210 days No hydrolysis observed 208 days
25 752 days 6641 days 106 days
50 87 days 290 days 4.9 days
60 27 days 95 days 47 hours
Reference
Description of key information
The half-life times of the test item were as follows:
pH 4 pH 7 pH 9
Temperature t½ t½ t½
[°C]
20 1210 days No hydrolysis observed 208 days
25 752 days 6641 days 106 days
50 87 days 290 days 4.9 days
60 27 days 95 days 47 hours
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 6 641 d
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.