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EC number: 638-734-4 | CAS number: 157248-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-04-12 to 2011-04-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.021 mg/L
- Temp.:
- 20 °C
- pH:
- >= 5.9 - <= 6.1
- Conclusions:
- The water solubility cs of the test item at a temperature of 20 °C was determined to be cs=0.021 mg/L (without correction for the purity).
- Executive summary:
A study was conducted in accordance with OECD TG 105 and Regulation (EC) No 440/2008 method A.6 to determine the water solubility of the test substance using the column elution method. The preliminary test showed that the water solubility of the test item is < 8.0 mg/L. The water solubility cs of the test item at a temperature of 20 °C was determined to be cs=0.021 mg/L (without correction for the purity).
Reference
Preliminary visual estimation of the water solubility
Different amounts of the test item and water were stirred at room temperature until the mixture appeared dissolved or the water solubility could be estimated to be below 10 mg/L.
Table 1: Appearance of the test mixtures
Amount of the test item in mg | Total volume In mL | Appearance of mixture |
10.4 | 100 | Undissolved 1) |
10.8 | 500 | Undissolved 1) |
4.0 | 500 | Undissolved 1) |
1) After adding the indicated amount of water, the solution was stirred at room temperature for about 1 day.
The solubility of the test item in water is below 8.0 mg/L (without correction of the purity). Therefore the water solubility had to be determined by the "column elution method".
Column elution method
Individual conditions
Column 1:
Rotation period of the fraction accumulator: 90 min per fraction
Average fraction volume: 15.3 mL
Flow rate: between 9.5 mL/h and 10.8 mL/h
Duration of sampling: about 72 h (46 fractions)
Column 2:
Rotation period of the fraction accumulator: 45 min per fraction
Average fraction volume: 17.9 mL
Flow rate: between 22.9 mL/h and 24.1 mL/h
Duration of sampling: about 72 h (96 fractions)
Column 3 (blank):
Rotation period of the fraction accumulator: 45 min per fraction
Average fraction volume: 17.5 mL
Flow rate: between 22.1 mL/h and 24.0 mL/h
Duration of sampling: about 72 h (96 fractions)
Concentration and pH
Table 2: Column-elution method: Column 1
Fraction no. | V in mL | pH | water solubility in µg/L |
35 | 14.6 | 5.9 | 21.1 |
36 | 14.5 | 6.1 | 22.3 |
37 | 14.5 | 6.0 | 21.4 |
38 | 14.5 | 6.1 | 19.3 |
39 | 14.4 | 5.9 | 21.6 |
According to the guideline the run can be stopped if the concentrations of five fractions do not differ more than ± 30 % without any raising or descending tendency.
Table 3: Column-elution method: Column 2
Fraction no. | V in mL | pH | water solubility in µg/L |
78 | 17.9 | 6.0 | 21.0 |
79 | 17.9 | 6.0 | 20.1 |
80 | 18.0 | 6.1 | 21.0 |
81 | 18.0 | 6.1 | 21.8 |
82 | 17.9 | 6.1 | 21.2 |
According to the guideline the run can be stopped if the concentrations of five fractions do not differ more than ± 30 % without any raising or descending tendency.
Table 4: Column-elution method: Column 3 (blank)
Fraction no. | V in mL | pH | water solubility in µg/L |
78 | 17.5 | 6.1 | <14 |
79 | 17.5 | 5.9 | < 14 |
80 | 17.6 | 6.1 | < 14 |
81 | 17.6 | 6.1 | < 14 |
82 | 17.6 | 6.1 | < 14 |
According to the guideline, the data of the fractions 1 to 5 were not taken into account for the following evaluation. The values for the water solubility were calculated from fractions 35 to 39 for column 1, from the fractions 78 to 82 for column 2, from the fractions 78 to 82 for column 3.
All other fractions were discarded.
Result column 1:
Evaluation of the fractions 35 to 39:
The water solubility was found to be: 0.021 mg/L (without correction of the purity)
Result column 2:
Evaluation of the fractions 78 to 82:
The water solubility was found to be: 0.021 mg/L (without correction of the purity)
Result column 3:
Evaluation of the fractions 78 to 82:
The blank concentration was found to be:< 0.014 mg/L.
Standards for recheck
Table 5: Concentrations of standards for recheck:
Standard | Measured concentration (µg/L) | % Recovery (mean value) |
Standard J (c = 7.075 µg/L) | 6.798 / 6.781 | 96.0 |
Standard H (c = 14.15 µg/L) | 13.64 / 13.58 | 96.2 |
Standard G (c = 283.0 µg/L) | 278.2 / 278.0 | 98.3 |
Standard i (c = 968.0 µg/L) | 926.0 / 925.7 | 95.6 |
Standard F (c = 2420 µg/L) | 2289 / 2290 | 94.6 |
The recovery of the 'recheck samples' is between 94.6 % and 98.3 %, indicating a sufficient accuracy of the analytical method.
All recovery values are calculated from the measured and unrounded concentration values and not from the rounded values given in table 5.
Coating check
Table 6: Coating check:
| Amount used for coating in mg | Measured concentration in mg/L | Amount eluted per column in mg |
Column 1 | 23.9 | 4.776 / 4.777 | 23.9 |
Column 2 | 23.9 | 4.817 / 4.814 | 24.1 |
The coating check was successful.
Description of key information
The water solubility cs of the test item at a temperature of 20 °C was determined to be cs=0.021 mg/L (without correction for the purity).
Key value for chemical safety assessment
- Water solubility:
- 0.021 mg/L
- at the temperature of:
- 20 °C
Additional information
A study was conducted in accordance with OECD TG 105 and Regulation (EC) No 440/2008 method A.6 to determine the water solubility of the test substance using the column elution method. The preliminary test showed that the water solubility of the test item is < 8.0 mg/L. The water solubility cs of the test item at a temperature of 20 °C was determined to be cs=0.021 mg/L (without correction for the purity).
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