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EC number: 632-556-0 | CAS number: 304859-44-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 January 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: Visual assessment
- Key result
- Water solubility:
- < 1 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 22 °C
- Remarks on result:
- other: pH not recorded.
- Details on results:
- In each case, undissolved orange coloured parts from the test material was observed in the flasks. The aquatic phase did not appear orange at any concentration.
The feasibility limit of this method for this test material was found to be about 0.5 mg/L by visual assessment. The test material was not soluble at the lowest feasible nominal concentration (0.5 mg/L).
In the partition coefficient study using HPLC-UV (High Performance Liquid Chromatography with UV detection) for chemical analysis some water soluble minor fractions were detected. They did not have any orange colour and were not similar to the main substance of the test material. Hence only the main test material was evaluated in this water solubility assessment. - Conclusions:
- Under the conditions of the study the water solubility of the test material was estimated to be < 1 mg/L by visual assessment.
- Executive summary:
The water solubility of the test material was assessed according to the standardised guidelines OECD 105 and EU Method A.6 and in compliance with GLP.
The test material could not be analysed for water solubility by a chemical analysis method due to the complex nature of the substance and the very low solubility. The water solubility of the test material was therefore estimated by visual assessment.
Approximately 10 mg portions of the test material were weighed into glass stoppered graduated cylinders and ultrapure water was added in steps. After each addition of water, the mixtures were shaken vigorously and were visually checked for any undissolved parts of the test material. The test was repeated with about 5 mg of test material. In both series, the test material did not dissolve in water, but it stuck to the wall of the glass vessels.
Because the test material is strongly coloured, it was feasible to continue the test at lower nominal concentrations of 2.5 mg and 1.0 mg of pulverised test material weighed into 2000 mL flasks, separately. Both flasks contained a small orange ball of test material.
The flasks and cylinders were ultrasonicated for about 10 minutes, which can cause a slight increase of the temperature and facilitate the dissolution.
Undissolved test material was observed at the 0.5 and 1 mg/L nominal concentration levels. The water solubility of the test material was therefore estimated to be < 1 mg/L.
Reference
Description of key information
Under the conditions of the study the water solubility of the test material was estimated to be < 1 mg/L by visual assessment.
Key value for chemical safety assessment
Additional information
The water solubility of the test material was assessed according to the standardised guidelines OECD 105 and EU Method A.6 and in compliance with GLP. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The test material could not be analysed for water solubility by a chemical analysis method due to the complex nature of the substance and the very low solubility. The water solubility of the test material was therefore estimated by visual assessment.
Approximately 10 mg portions of the test material were weighed into glass stoppered graduated cylinders and ultrapure water was added in steps. After each addition of water, the mixtures were shaken vigorously and were visually checked for any undissolved parts of the test material. The test was repeated with about 5 mg of test material.In both series, the test material did not dissolve in water, but it stuck to the wall of the glass vessels.
Because the test material is strongly coloured, it was feasible to continue the test at lower nominal concentrations of 2.5 mg and 1.0 mg of pulverised test material weighed into 2000 mL flasks, separately. Both flasks contained a small orange ball of test material.
The flasks and cylinders were ultrasonicated for about 10 minutes, which can cause a slight increase of the temperature and facilitate the dissolution.
Undissolved test material was observed at the 0.5 and 1 mg/L nominal concentration levels. The water solubility of the test material was therefore estimated to be < 1 mg/L.
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