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EC number: 630-324-3 | CAS number: 861229-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: not irritating
Eye irritation: not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 25, 1992 - September 1, 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Version / remarks:
- EPA FIFRA Subdivision F Guideline 81-5 Primary dermal irritation, revised Edition November 1984
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- batch No.of test material: 5007
- sample No.:1505E
- Expiration date of the lot/batch: March 1993
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: 4°C in the dark - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield (U.K.) Ltd., Petersfield, Hampshire, England
- Age at study initiation: 10-14 weeks
- Weight at study initiation: 2.4 to 3.0 kg
- Housing:ndividually in plastic cages with perforated floors
- Diet: ad libitum, Standard laboratory diet SDS Stanrab
- Water: ad libitum
- Acclimation period: yes
ENVIRONMENTAL CONDITIONS
- Temperature (°C): maintained at approximately 19°C
- Humidity (%): 30-70%
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light):12/12
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- single treatment
- Observation period:
- 8 days
- Number of animals:
- six
- Details on study design:
- TEST SITE
- Area of exposure: dorsal area of 25mm2
- % coverage: 25 mm x 25 mm
- Type of wrap if used: gauze pad, covered with "Elastoplast" elastic adhesive dressing
REMOVAL OF TEST SUBSTANCE
- Washing: with warm water ( 30°- 40°C)
- Time after start of exposure: 4 hours
OBSERVATION TIME POINTS
- on Day 1 ( approximately 30 minutes after removal of the dressings)
- on Day 2, 3 and 4 (= 24h, 48h and 72h)
- additional observations were made on Days 5 to 8
SCORING SYSTEM:
- Method of calculation: Local dermal irritation was assessed using the prescribed numerical system:
Erythema and eschar formation:
No erythema 0
Very slight erythrema (barely perceptible) 1
well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth) 4
Oedema formation:
No oedema 0
Very slight oedema (barely perceptible) 1
Slight oedema (edges of area well-defined by definite raising) 2
Moderate oedema (raised approximately 1 millimetre) 3
Severe oedema (raised more than 1 millimetre and extending beyond the area of exposure) 4 - Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0.8
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritant / corrosive response data:
- Very slight erythrema was observed in a single animal only immediately after the removal of the dressings. By Day 2 very slight to well-defined erythema with or without very slight to slight edema was seen in all animals. Very slight erythema accompanied by very slight edema was observed in all animals on Day 3. All dermal reactions had resolved in three animals by Day 4 and in a further animal by Day 5. In the remaining two rabbits very slight dermal reactions persisted up to and including Day 7.
- Other effects:
- There were no signs of toxicity or ill health in any rabbit during the observation period.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- MCPP-P 2-EHE showed no skin irritation potential.
- Executive summary:
A dermal skin irritation study to assess the skin irritation potential of MCPP-P 2-EHE was performed. The method followed was that described in EPA Pesticide Assessment Guidelines, Subdivision F. Hazard Evaluation: Human and Domestic animals 81-5 Primary dermal irritation (Version 1984). Six rabbits were each administered a single dermal dose of 0.5 mL of the test substance and observed for a maximum of eight days. A single semi-occlusive application of MCPP-P 2-EHE to intact skin for 4 hours elicited very slight to well-defined dermal reactions, while all reactions had resolved by day 8. The mean value for erythema was not higher than 1.3 and the mean value for edema was not higher then 1 (according Draize score).
Reference
Table 1: Dermal reactions observed after application of MCPP-P 2-EHE
Rabbit number (# animal) |
E = Erythema O= Oedema |
Day |
1* 2 3 4 5 6 7 8 |
||
1 (male) |
E O |
0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 1 0 0 0 0 0 1 2 1 1 1 1 1 0 0 1 1 1 1 1 1 0 0 2 1 0 0 0 0 0 0 1 1 0 0 0 0 0 0 1 1 1 0 0 0 0 0 2 1 0 0 0 0 0 0 1 1 1 1 1 1 0 0 1 1 1 1 1 1 0 |
2 (male) |
E O |
|
3 (male) |
E O |
|
4 (male) |
E O |
|
5 (male) |
E O |
|
6 (male) |
E O |
*Approximately 30 min after removal of the dressing
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1, 1992 - September 15, 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- Version / remarks:
- EPA FIFRA Subdivision F Guideline 81-4 Primary eye irritation, revised Edition November 1984
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- batch No.of test material: 5007
- sample No.:1505E
- Expiration date of the lot/batch: March 1993
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: 4°C in the dark - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Interfauna U.K. Ltd., Huntingdon, Cambridgeshire, England (5) and 1 from Froxfield U.K. Ltd., Petersfield, Hampshire, England
- Age at study initiation: 11- 14 weeks
- Weight at study initiation: 2.6 to 3.1 kg
- Housing: individually in plastic cages with perforated floors
- Diet: ad libitum (Standard laboratory diet SDS Stanrab Rabbit Diet)
- Water: ad libitum
- Acclimation period: yes
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19°C
- Humidity (%): 30 -70%
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL placed into the lower everted lid of one eye of each animal.
- the eyelids were then gently held together for one second before releasing - Duration of treatment / exposure:
- single
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6 animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: eyes were not washed 24 h after treatment
SCORING SYSTEM:
Examination of the eyes was made after 1 hour and 1, 2, 3 days (equivalent to 24, 48 and 72 hours after instillation), 4 and 7 days after instillation
Ocular irritation was assessed using the prescribed numerical system:
Cornea:
opacity: degree of density (area most dense taken for reading)
No ulceration or opacity 0
Scattered or diffuse areas of opacity (other than slight dulling of nuermal lustre,
details of iris clearly visible 1*
Easily discernible translucent areas, details of iris slightly obscured 2*
Nacreous areas, no details of iris visible, size of pupil barely discernible 3*
Opaque cornea, iris not discernible through the opacity 4*
Iris:
Normal 0
Markedly deepened rugae, congestion, swelling, moderate circumcorneal
hyperaemia or injection, any of these or combination of any thereof, iris still
reacting to light (sluggish reaction positive) 1*
No reaction to light, haemorrhage, gross destruction (any or all of these) 2*
Conjunctivae:
Redness (refers to palpebral and bulbar conjunctivae, excluding cornea and iris)
Blood vessels normal 0
Some blood vessels definitely hyperaemic (injected) 1
Diffuse, crimson colour, individual vessels not easily discernible 2*
Diffuse beefy red 3*
Chemosis (lids and/or nictating membranes)
No swelling 0
Any swelling above normal (includes nictating membranes9 1
Obvious swelling with partial eversion of lids 2*
Swelling with lids about half-closed 3*
Swelling with lids more than half-closed 4*
Discharge
No discharge 0
Any amount different from normal (does not include small amounts observed
in inner canthus of normal animals) 1
Discharge with moistening of the lids and hairs just adjacent to lids 2
Discharge with moistening of the lids and hairs, and considerable area
around the eye 3
*interpreted as a positive effect
TOOL USED TO ASSESS SCORE: handheld lamp - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal#1
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal#1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Remarks:
- animal#1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal#1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal#2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal#2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Remarks:
- animal#2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal#2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal#3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal#3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Remarks:
- animal#3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal#3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal#4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal#4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Remarks:
- animal#4
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal#4
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal#5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal#5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Remarks:
- animal#5
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal#5
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animal#6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal#6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Remarks:
- animal#6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal#6
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Other effects:
- There were no signs of toxicity or ill health in any rabbit during the observation period.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Instillation of MCPP-P 2-EHE into the rabbit eye elicited a positive response in all of the six treated animals according to EPA FIFRA test critaria, which all resolved seven days after instillation.
- Executive summary:
A GLP-Study to assess the eye irritation potential of MCPP-P 2-EHE on rabbits was performed. The method followed was that described in EPA Pesticide Assessment Guidelines, Subdivision F. Hazard Evaluation: Human and Domestic Animals 81-4 Primary eye irritation (Version 1984). Six rabbits were each administered a single ocular dose of 0.1 mL of the test item and observed for a maximum of seven days after instillation. The administration into the eye of the rabbit elicited corneal opacification in one animal and mild conjunctival irritation. According to Draize score, only one animal showed a corneal opacity (mean score of 2.3), while mean conjunctival redness, chemosis and iris effects were not scored higher than 1 and all reactions had resolved seven days after instillation.
Reference
Table 1: Ocular reactions observed after instillation of MCPP-P 2-EHE
Rabbit number (#) |
Region of the eye |
One hour |
Days after instillation |
Result Positive (+) Negative (-) |
|
|
1 2 3 4 7 |
+ |
|||
Animal #1 (male)* |
Cornea |
Density |
0 |
3 2 2 1 0 |
|
Iris |
0 |
0 0 0 0 0 |
|||
Conjunctiva |
Redness |
2 |
1 1 1 1 0 |
||
Chemosis |
1 |
1 1 0 0 0 |
|||
Discharge |
2 |
1 1 0 0 0 |
|||
Animal #2 (female) |
Cornea |
Density |
0 |
0 0 0 0 0 |
+ |
Iris |
0 |
0 0 0 0 0 |
|||
Conjunctiva |
Redness |
2 |
2 1 0 0 0 |
||
Chemosis |
1 |
1 0 0 0 0 |
|||
Discharge |
2 |
1 0 0 0 0 |
|||
Animal #3 (female) |
Cornea |
Density |
0 |
0 0 0 0 0 |
+ |
Iris |
0 |
0 0 0 0 0 |
|||
Conjunctiva |
Redness |
2 |
2 1 0 0 0 |
||
Chemosis |
1 |
1 0 0 0 0 |
|||
Discharge |
2 |
1 0 0 0 0 |
|||
Animal #4 (female) |
Cornea |
Density |
0 |
0 0 0 0 0 |
+ |
Iris |
0 |
0 0 0 0 0 |
|||
Conjunctiva |
Redness |
2 |
2 1 0 0 0 |
||
Chemosis |
1 |
1 0 0 0 0 |
|||
Discharge |
2 |
1 0 0 0 0 |
|||
Animal #5 (female) |
Cornea |
Density |
0 |
0 0 0 0 0 |
+ |
Iris |
0 |
0 0 0 0 0 |
|||
Conjunctiva |
Redness |
2 |
2 1 0 0 0 |
||
Chemosis |
1 |
1 0 0 0 0 |
|||
Discharge |
2 |
1 0 0 0 0 |
|||
Animal #6 (female) |
Cornea |
Density |
0 |
0 0 0 0 0 |
+ |
Iris |
0 |
0 0 0 0 0 |
|||
Conjunctiva |
Redness |
2 |
2 1 0 0 0 |
||
Chemosis |
1 |
1 0 0 0 0 |
|||
Discharge |
2 |
1 0 0 0 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
A dermal skin irritation study to assess the skin irritation potential of MCPP-P 2-EHE was performed. The method followed was that described in EPA Pesticide Assessment Guidelines, Subdivision F. Hazard Evaluation: Human and Domestic animals 81 -5 Primary dermal irritation (Version 1984). Six rabbits were each administered a single dermal dose of 0.5 mL of the test substance and observed for a maximum of eight days. A single semi-occlusive application of MCPP-P 2-EHE to intact skin for 4 hours elicited very slight to well-defined dermal reactions, while all reactions had resolved by day 8. The mean value for erythema was not higher than 1.3 and the mean value for edema was not higher then 1 (according Draize score; MCPP-p Task Force 920812D/JEL 73/SE; 1992).
Eye irritation
A GLP-Study to assess the eye irritation potential of MCPP-P 2-EHE on rabbits was performed. The method followed was that described in EPA Pesticide Assessment Guidelines, Subdivision F. Hazard Evaluation: Human and Domestic Animals 81 -4 Primary eye irritation (Version 1984). Six rabbits were each administered a single ocular dose of 0.1 mL of the test item and observed for a maximum of seven days after instillation. The administration into the eye of the rabbit elicited corneal opacification in one animal and mild conjunctival irritation. According to Draize score, only one animal showed a corneal opacity (mean score of 2.3), while mean conjunctival redness, chemosis and iris effects were not scored higher than 1 and all reactions had resolved seven days after instillation (MCPP-p Task Force 920824D/JEL 74/SE; 1992 ).
In conclusion, MCPP-P 2-EHE showed no persistent or classifiable skin or eye irritating effect. All reactions had resolved by 8 days.
Justification for classification or non-classification
Classification,
Labelling, and Packaging Regulation (EC) No 1272/2008
The
available experimental test data are reliable and suitable for
classification purposes under Regulation (EC) No 1272/2008. The
substance is not considered to be classified for skin or eye irritation
under Regulation (EC) No 1272/2008, as amended for the tenth time in
Regulation (EU) No 2017/776.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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