Registration Dossier
Registration Dossier
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EC number: 931-371-5 | CAS number: 171171-80-5
Endpoint summary
Administrative data
Description of key information
GLP study reporting the substance to be non-irritating to rabbit skin (OECD 404).
Non-GLP study reporting moderately irritating to rabbit skin after 24 h exposure under an occlusive dressing
GLP study reporting initial irritation to rabbit eyes which had cleared by 7 d (OECD 405)
Non-GLP study reporting the test substance to be a mild irritant to rabbit eyes
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
SKIN IRRITATION
A non-GLP study found a single application of the test material to occluded rabbit skin was moderately irritating after an exposure period of 24 h. However, a modern GLP study reported minimal erythema at 24 h progressing to moderate inflammation by 72 h post dosing where all effects had cleared within 14 days. The levels and/or sustainability of irritation were not sufficient for classification (CLP/DSD).
EYE IRRITATION
A non-GLP study considered the test material to be mildly irritating to rabbit eyes. However, a more modern GLP study reported no initial pain response and found moderate conjunctival redness in all six rabbits and minimal corneal opacity in three rabbits had completely cleared by 7 days. The results did not warrant classification for eye irritation (CLP/DSD).
Justification for classification or non-classification
SKIN IRRITATION
Study results do not lead to classification as a skin irritant under the terms of Directive 67/548/EEC or Regulation (EC) 1272/2008.
EYE IRRITATION
Study results do not lead to classification as an eye irritant under the terms of Directive 67/548/EEC or Regulation(EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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