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EC number: 908-996-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There are two studies available on the skin irritancy potential. A 1:10 dilution of Reaction mass of Methyl dihydrogen phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate was tested for its skin irritant properties in 3 or 5 Yellow-silver strain rabbits. The study was similar to OECD Guideline 404. Effects on the skin (necrosis and scrabby skin) were observed all animals after application. Therefore, it is concluded that the undiluted reaction mass of Methyl dihydrogen phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate is corrosive.
There are two studies available on the eye irritancy potential. A 1:20 dilution of Reaction mass of Methyl dihydrogen phosphoric phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate was tested for its eye irritant properties in 3 or 5 Yellow-silver strain rabbits. The study was similar to OECD Guideline 405.
The application of a 1:10 dilution of the test substance to the eyes of 3 rabbits lead to moderate opacity, slight reddening and swelling of the conjunctivae.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- April 1968
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study design follows the "Barail-Test"; summary report
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Barail Test
- Deviations:
- not specified
- Principles of method if other than guideline:
- The test substance was applied in dilutions (1:10 and 1:30) to rabbit`s skin on 5 consecutive days.
- GLP compliance:
- no
- Remarks:
- performed before GLP
- Species:
- rabbit
- Strain:
- other: Yellow-silver strain
- Details on test animals or test system and environmental conditions:
- TEST ANIMAL
- Housing: individually
- Diet (e.g. ad libitum): Standard Altromin K (Altrogge, Lage/Lippe, Germany), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum - Type of coverage:
- not specified
- Preparation of test site:
- clipped
- Vehicle:
- physiological saline
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL of 1:10 or 1:30 dilution
- Duration of treatment / exposure:
- once every day on 5 consecutive days
- Observation period:
- 5 days
- Number of animals:
- 5
- Details on study design:
- no data
- Irritation parameter:
- erythema score
- Remarks:
- only description of skin reaction available; non guideline study
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- only description of skin reaction available; non guideline study
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- 1:10 dilution: slightly reddened, scrabby skin
1:30 dilution: no effects - Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The application of a 1:10 dilution the test substance on 5 consecutive days to the clipped skin of 5 rabbits lead to slightly reddened scrabby skin. Therefore, it is concluded that the undiluted reaction mass of Methyl dihydrogen phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate is irritant at least.
- Executive summary:
The test substance was applied in dilutions (1:10 and 1:30) to rabbit`s skin on 5 consecutive days. The 1:10 dilution lead to skin reddened scrabby skin. No effects were observed after the repeated application of the 1:30 dilution.
Reference
Observed effects:
1:10 dilution: slightly reddened, scrabby skin
1:30 dilution: no effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Apr 1968
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study design similar to OECD Guideline with some deviations; summary report
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- dilutions tested
- GLP compliance:
- no
- Remarks:
- performed before GLP
- Species:
- rabbit
- Strain:
- other: Yellow-silver strain
- Details on test animals or tissues and environmental conditions:
- TEST ANIMAL
- Housing: individually
- Diet (e.g. ad libitum): Standard Altromin K (Altrogge, Lage/Lippe, Germany), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum - Vehicle:
- physiological saline
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL of 1:10 or 1:100 dilution
- Duration of treatment / exposure:
- The eyes were not washed after application.
- Observation period (in vivo):
- 1 hour post application
3 hour post application
7 hour post application
24 hours post application
48 hours post application
72 hours post application - Number of animals or in vitro replicates:
- 5
- Details on study design:
- After treatment the eyes were not washed out.
- Irritation parameter:
- cornea opacity score
- Remarks:
- only qualitiative description of the effects in the eye available, non guideline study
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- iris score
- Remarks:
- only qualitiative description of the effects in the eye available, non guideline study
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Irritant / corrosive response data:
- - 1:10 dilution:
eye slightly reddened, moderate opacity and swelling of the conjunctivae
- 1:100 dilution:
eye slightly reddened; effects reversible within 1h - Other effects:
- no further data
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The application of a 1:10 dilution of the test substance to the eyes of 5 rabbits lead to moderate opacity, reddening and swelling of the conjunctivae.
Therefore it is concluded that the undiluted reaction mass of Methyl dihydrogen phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate has to be classified as irritant to the eyes (R41 - Risk of serious damage to the eyes; H318 - Causes serious eye damage) according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC). - Executive summary:
A 1:10 and 1:100 dilution of reaction mass of Methyl dihydrogen phosphateand Orthophosphoric acid and Dimethyl hydrogen phosphate were tested for its eye irritant properties in 5 rabbits.The study was performed similar to OECD Guideline 405.
The application of a 1:10 dilution of the test substance to the eyes of 3 rabbits lead to moderate opacity, slight reddening and swelling of the conjunctivae.
Therefore it is concluded that the undiluted reaction mass of Methyl dihydrogen phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate has to be classified as irritant to the eyes (R41 - Risk of serious damage to the eyes; H318 - Causes serious eye damage) according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Reference
Observed effects:
- 1:10 dilution:
eye slightly reddened, moderate opacity and swelling of the conjunctivae
- 1:100 dilution:
eye slightly reddened; effects reversible within 1h
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation: 2 studies available: corrosive; 1 read across available: corrosive
Eye irritation: 2 studies available: corrosive
There are two studies
available on the skin irritancy potential. A 1:10 dilution of Reaction
mass of Methyl dihydrogen phosphate and Orthophosphoric acid and
Dimethyl hydrogen phosphate was tested for its skin irritant properties
in 3 or 5 Yellow-silver strain rabbits. The study was similar to OECD
Guideline 404. Effects on the skin (necrosis and scrabby skin) were
observed all animals after application. Therefore, it is concluded that
the undiluted reaction mass of Methyl dihydrogen phosphate and
Orthophosphoric acid and Dimethyl hydrogen phosphate is corrosive.
In another skin irritation study performed with Phosphoric acid, butyl
ester which was taken for read across purposes, the substance was
applied to the clipped skin of one White Russian rabbit. Effects on the
skin (erythema grades up to 4 and edema scores up to 4 as well as
necrosis) were observed 1 hour after application.These signs were
not reversible within 14 days.
The substance tested in the present skin irritation study,
Phosphoric acid, butyl ester, and the substance to be registered,
Reaction mass of Methyl dihydrogen phosphate and Orthophosphoric acid
and Dimethyl hydrogen phosphate are both members of the Phosphoric acid,
alkyl ester family. The characteristic and active functionalities of
this substance category are the central ester binding and the free
hydroxyl group(s) for which most of the Phosphoric acid, alkyl esters
are proven to be corrosive. Both Phosphoric esters have a very low pKa
(Reaction mass of Methyl dihydrogen phosphate: 2.6 (first step);
Phosphoric acid, butyl ester: 2.5 (first step)) value indicating the
strong tendency to set free protons, which themselves are responsible
for the pH and consequently for the skin/eye corrosive properties of the
short chain Phosphoric acid, alkyl esters. Since the Reaction mass of
Methyl dihydrogen phosphoric phosphate and Orthophosphoric acid and
Dimethyl hydrogen phosphate takes over an intermediate role between
Orthophosphoric acid and Phosphoric acid, butyl ester (both corrosive)
with reference to its physical-chemical and structural properties a read
across between Phosphoric acid, butyl ester and Phosphoric acid, methyl
ester is supposed to be justified.
With reference the reported scores and the presence of necrotic skin Reaction mass of Methyl dihydrogen phosphoric phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate has to be classified as corrosive to the skin (H314 – Causes severe skin burns and eye damage) according to the criteria laid down in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
There are two studies available on the eye irritancy potential. A 1:20 dilution of Reaction mass of Methyl dihydrogen phosphoric phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate was tested for its eye irritant properties in 3 or 5 Yellow-silver strain rabbits. The study was similar to OECD Guideline 405.
The application of a 1:10 dilution of the test substance to the eyes of 3 rabbits lead to moderate opacity, slight reddening and swelling of the conjunctivae.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
With reference the reported scores and the presence of necrotic skin Reaction mass of Methyl dihydrogen phosphoric phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate has to be classified as corrosive to the skin (H314 – Causes severe skin burns and eye damage) according to the criteria laid down in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
It is concluded that reaction mass of Methyl dihydrogen phosphate and Orthophosphoric acid and Dimethyl hydrogen phosphate has to be classified as irritant to the eyes (R41 - Risk of serious damage to the eyes; H318 - Causes serious eye damage) according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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