6 alpha-Fluoro-16 alpha-methyl-21-valeryloxy-1,4,9(11)-pregnatriene-3,20-dione

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 Jan to 09 Aug 2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

other: EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD Guideline 102 (Melting point / Melting Range)

Deviations:

not applicable

GLP compliance:

no

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Type of method:

differential thermal analysis

Remarks:

Differential Thermal Analysis (DTA) / Differential Scanning Calorimetry (DSC)

Key result

Remarks on result:

not determinable

Remarks:

Since there were no further evidences for a boiling point of the test item, it can be stated that the test item has no boiling point

RESULTS:

- Endothermic phases between approx. 45 °C – 75 °C (This endothermic phase could be a glass transition)

- Exothermic phases between approx. 78–103 °C, approx. 215 and 280 °C and approx. 320 to 450 °C

- No boiling point or range was visible throughout the whole temperature range.

 

Since there were no further evidences for a boiling point of the test item it can be stated that the test item has no boiling point. No further investigations were made.

 

Validity criteria for the measurement of the boiling point:

Target condition according to guideline OECD 103:	Actual condition according to the study:	Validity criteria met:
The heating rate should not exceed 10 K/min.	Heating rate was 5 K/min.	Yes
The mean of at least two measurements which are in the range of the estimated accuracy (accuracy for this method according to the guideline is +/- 0.5 K up to 600 K) is reported as the boiling temperature.	One determination was done with no determination of a boiling point.	No.
The measured boiling temperatures and their mean shall be stated and the pressure(s) at which the measurements were made shall be reported in kPa. The pressure should preferably be close to normal atmospheric pressure.	The atmospheric pressure is not stated.	No. Nevertheless, although the pressure is not stated one can assume that the study was performed at atmospheric pressure as the study was performed according to guideline 92/69/EWG A.2, where specifications for the pressure are stated ("the boiling temperature is stated with regard to the ambient pressure during the measurement").

 

Conclusions:

Up to the decomposition of the substance no definite boiling point was observed.

Executive summary:

A differential thermoanalysis method (DTA) was used to determine the thermal stability and decomposition point. It was perfomed according to the procedure Test method A.1 "Melting/Freezing Temperature" described in the EC-Guideline. Up to the decomposition of the test item no definite boiling point was observed. Between approx. 78 -103 °C, approx. 215 and 280 °C and approx. 320 to 450 °C the substance showed exothermic phases. A melting point could be detected between 124-127 °C. No boiling point or range was visible throughout the whole temperature range. Since there were no further evidences for a boiling point of the test item it can be stated that the test item has no boiling point. No further investigations were made.

Description of key information

Since there were no further evidences for a boiling point of DELTA-9(11)-Fluocortolon-Valerat found, it can be stated that the substance has no boiling point.

Additional information

Between approx. 78 – 103 °C, approx. 215 and 280 °C and approx. 320 to 450 °C the substances showed exothermic phases. No boiling point or range was visible throughout the whole temperature range. Since there were no further evidences for a boiling point of the substance it can be stated that the substance has no boiling point. No further investigations were made.