Registration Dossier
Registration Dossier
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EC number: 928-729-8 | CAS number: 188416-20-8
Endpoint summary
Administrative data
Description of key information
Skin irritation:
A skin irritation study to rabbit (Brenda, 1998) is available which is key study. This study showed the a single semi-occlusive application of this substance to intact rabbit skin for up to four hours elicited well-defined dermal irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
A skin irritation study to rabbit (Brenda, 1998) was conducted according to OECD 404. This study showed the a single semi-occlusive application of this substance to intact rabbit skin for up to four hours elicited well-defined dermal irritation.
Justification for selection of skin irritation / corrosion endpoint:
Study run to a method comparable with current guidelines and to GLP
Effects on skin irritation/corrosion: moderately irritating
Justification for classification or non-classification
Skin irritation/corrosion: Mean scores at 24, 48 & 72 hours for erythema were < 2.3 (actual value 1.44), for oedema were < 2.3 (actual value 0.22).
Therefore in accordance with Regulation (EC) No. 1272/2008 Tables 3.2.2 , the substance is not classified for the skin corrosion/irritation endpoint.
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