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EC number: 685-540-0 | CAS number: 208126-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 Sept 2007 - 10 Jan 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 7-2-A
- Expiration date of the lot/batch: April 2010
- Purity test date: not stated
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature at about 20 °C, away from direct sunlight.
- Stability under test conditions: not stated
- Solubility and stability of the test substance in the solvent/vehicle: insoluble in water
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: none
- Preliminary purification step (if any): none
- Final dilution of a dissolved solid, stock liquid or gel: 250.5 mg Salacos 168 ARV in 2500 mL test water, WAF used - Analytical monitoring:
- yes
- Details on sampling:
- For the 48-hour stability samples, additional flasks with adequate volumes of the freshly prepared test medium and of the control were incubated during the test period under the same conditions as in the actual test. Sampling from the test beakers with daphnids was not possible because the test medium volume per beaker (50 mL) was too small for the analytical requirements.
All samples were stored deep-frozen (at about -20 °C) immediately after sampling. - Vehicle:
- no
- Details on test solutions:
- In order to assess the toxicity to daphnids of the test item containing different components, a water accommodated fraction (WAF) with the loading rate of 100 mg/L was prepared by mixing 250.5 mg of the test item into 2500 ml of test water using ultrasonic treatment for 15 minutes at room temperature in the dark. The dispersion was stirred for 96 hours to dissolve a maximum amount of the different compounds of the test item in the dispersion. Then, the dispersion was filtered through a membrane filter (0.45 µm pore size) and the undiluted filtrate was tested as WAF.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: Daphnia magna Straus
- Justification for species other than prescribed by test guideline:
- Source: University of Sheffield
- Age of parental stock (mean and range, SD): 6-24 hours
- Feeding during test no
- Food type: none feed
- Amount: none feed
- Frequency: none feed
ACCLIMATION
no acclimation
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 2.5 mmol/L
- Test temperature:
- 21 °C
- pH:
- 7.9
- Dissolved oxygen:
- 8.1 - 8.7 mg/L
- Nominal and measured concentrations:
- nominal: 100 mg/L loading rate for WAF
measured: LOQ - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 ml glass beakers
- Type (delete if not applicable): not stated
- Material, size, headspace, fill volume: glass, 100 ml, 50 ml test medium
- Aeration: not stated
- Type of flow-through (e.g. peristaltic or proportional diluter): no flow through
- Renewal rate of test solution (frequency/flow rate): no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
- Biomass loading rate: not stated
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: not stated
- Total organic carbon: not stated
- Particulate matter: not stated
- Metals: not stated
- Pesticides: not stated
- Chlorine: not stated
- Alkalinity: not stated
- Ca/mg ratio: 4
- Conductivity: not stated
- Salinity: not stated
- Culture medium different from test medium: no
- Intervals of water quality measurement: not stated
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: 490 to 650 Lux - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Remarks:
- Water accomodated fraction
- Basis for effect:
- mobility
- Reported statistics and error estimates:
- no statistics performed
- Validity criteria fulfilled:
- yes
- Conclusions:
- In conclusion, the test item Salacos 168 ARV had no acute toxic effects to Daphnia magna up to its solubility limit in test water under the present test conditions.
- Executive summary:
The acute toxicity of the test item Salacos 168 ARV to Daphnia magna was deteermined in a 48 hour static test according to the EUCommission Directive 92/69/EEC, Part C.2 (1992) and the OECD Guideline for Testing of Chemicals, No. 202 (2004).
A limit test was performed in compliance with the test guidelines to demonstrate that water accommodated fractions (WAFs) of the test item have no toxic effect on Daphnia magna up to the loading rate of 100 mg/L. Thus, the only concentration tested was a WAF with the loading rate of 100 mg/L. Additionally, a control (test water without test item) group was tested in parallel. The test method was based on the OECD Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures, 2000.
For the preparation of the test medium, a dispersion was stirred for 96 hours to dissolve a maximum amount of the different compounds of the test item in the dispersion. Then, the dispersion was filtered through a membrane filter (0.45 µm pore size) and the undiluted filtrate was tested as WAF.
The analytically measured test item concentration in the test medium was below the limit of quantification (0.1 mg/L) at the beginning and the end of the test period of 48 hours. Since a WAF of the test item with sparingly solublecomponents was tested, all reported biological results are based on the loading rate of 100 mg/L.
In the control and at the loading rate of 100 mg/L, no immobilized daphnids were determined during the test period of 48 hours.
The 48 hours NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours) of Salacos 168 ARV to Daphnia magna were determined to be at least at the loading rate of 100 mg/L. These values might even be higher but loading rates in excess of 100 mg/L were not tested, in accordance with the test guidelines. The 48 hour EC50 and the 48 hour EC100 were clearly higher than the loading rate of 100 mg/L. These values could not be quantified due to the absence of toxictiy of Salacos 168 ARV at the loading rate of 100 mg/L.
Reference
Description of key information
One Guideline Study performed. Water accomodated Fractions with loading rates up to 100 mg/l tested.
No toxic effects observed up to the highest loading rate.
Key value for chemical safety assessment:
EC50, EC10 > 100 mg/L, 100 mg/L entered in respective field below
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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