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EC number: 606-883-4 | CAS number: 219921-94-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 November 1998 - 8 April 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 301 D) and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (S)-3-Methyl-1-(2-piperidine-1-phenyl)butylamine compound with N-Acetyl-L-glutamic acid
- EC Number:
- 606-883-4
- Cas Number:
- 219921-94-5
- Molecular formula:
- C16-H26-N2 x C7-H11-N-O5
- IUPAC Name:
- (S)-3-Methyl-1-(2-piperidine-1-phenyl)butylamine compound with N-Acetyl-L-glutamic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): AGEE 623 Glutaminate; L-Glutamic acid, N-acetyl-, compd. with (S)-alpha-(2)-methylpropyl)-2-(1-piperidinyl)-benzenemethanamine
- Molecular formula (if other than submission substance): C16H26N2 * C7H11NO5
- Molecular weight (if other than submission substance): 435.57 g/mol
- Structural formula attached as image file (if other than submission substance): see reference substance
- Physical state: solid white powder
- Analytical purity: 100% (4% of (R)-(-) enantiomer
- Purity test date: 28 October 1998
- Lot/batch No.: T29725
- Expiration date of the lot/batch: 31 December 1999
- Stability under test conditions: pure: see epiry date; in water: for at least 2 hours
- Storage condition of test material: in original container, at room temperature, in the dark
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): supplied by sewage plant Groß-Zimmern, Germany
The activated sludge used for this study was washed by centrifugation and the supernatant liquid phase was decanted. The solid material was resuspended in tap water and again centrifuged. This procedure was repeated twice. An aliquot of the final sludge to its dry weight was determined. Based on this ratio, calculated aliquots of washed sludge suspension, corresponding to 4 g dry material per litre were mixed with test water and then areated until use. Before use the sludge was filtered through cotton wool. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2.14 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: grade salts were added to deionised water to give stock solutions. Stock solutions were diluted in deionised water, aerated for 20 minutes and allowed to stand for 20 hrs at the test temperature. Dissolved oxygen concentration was about 8.6 - 9.2 mg/L prior to starting the test.
- Test temperature: 21.3 - 22.3°C
- pH: 7.4 - 7.5
TEST SYSTEM
- Culturing apparatus: 250 ml flasks with glass stoppers
- Number of culture flasks/concentration: 16 bottles containing the test substance and inoculum; 16 bottles containing the reference compound Aniline and Inoculum (procedure control); 16 bottles containing only inoculum (inoculum control); 10 bottles containing the test substance, reference compound Aniline and inoculum (toxicity control)
- Method used to create aerobic conditions: inoculum and medium solutions were sufficiently aerated prior to the start of the test.
- Measuring equipment: O2 electrode
- Test performed in closed vessels: yes
SAMPLING
- Sampling frequency: oxygen was measured at days 0, 2, 5, 7, 12, 14, 21 and 28 after the start of the test.
- Sampling method: no sampling was performed for oxygen analysis, the oxygen concentrations were measured with an oxygen meter with a stirring O2 electrode.
- Sterility check if applicable: no
- Sample storage before analysis: no
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: no
- Toxicity control: yes
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 26.1
- Sampling time:
- 28 d
- Details on results:
- The residual oxygen concentration did not drop below 0.5 mg O2/L at any time. The difference in duplicate samples was less than 20%.
BOD5 / COD results
- Results with reference substance:
- The percentage biodegradation of the reference compound confirms the suitability of the used activated sludge inoculum. According to the test guidelines the test substance can be assumed to be not inhibitory on the activated sludge micro organisms because degradation was >25% within 14 days.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- The percentrage biodegradation did not exceed 60% within the 10 day window. The test substance can therefore not considered to be readily
biodegrdable
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