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EC number: 606-661-7 | CAS number: 208709-55-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-11-19 to 2005-01-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study performed according to OECD 305 and METI Guideline: Concentration Test on Chemical Substances in Fish
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Qualifier:
- according to guideline
- Guideline:
- other: METI Guideline: Concentration Test on Chemical Substances in Fish
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals/frequency for test organisms: days 0, 7, 14, 21, 26, 28
- Vehicle:
- yes
- Details on test solutions:
- According to guideline PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)- Chemical name of vehicle (organic solvent, emulsifier or dispersant): SPAN 20- Concentration of vehicle in test medium (stock solution and final test solution(s) at different concentrations and in control(s)): Dose 1: Test item: 0.1 mg/L , Vehicle: 0.5 mg/LDose 2: Test item: 0.01 mg/L , Vehicle: 0.05 mg/LControl: Test item: --, Vehicle: 0.5 mg/L
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- Lot No. 40726 from 2004-07-26
Weight: 2.11 +/- 0.21 g
Length: 5.7 +/- 0.20 cm - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Hardness:
- 250 mg/L
- Test temperature:
- 25.6 ° +/- 0.4 °C
- pH:
- 7.2 +/- 0.1
- Dissolved oxygen:
- 7.3 +/- 0.4 mg/L
- Nominal and measured concentrations:
- nominal concentration 0.1 mg/L: analytically measured concentrations: day 0: 0.0926 mg/Lday 7: 0.0913 mg/L day 14: 0.0995 mg/Lday 21: 0.0102 mg/Lday 26: 0.0876 mg/Lday 28: 0.0102 mg/Lnominal concentration 0.01 mg/Lanalytically measured concentrations:day 0: 0.00856 mg/Lday 7: 0.00967 mg/L day 14: 0.00955 mg/Lday 21: 0.00826 mg/Lday 26: 0.00817 mg/Lday 28: 0.00985 mg/L
- Details on test conditions:
- After acclimatisation period, the fish (Cyprinus carpio) were transferred into the test media under flow through conditions. Exposure concentrations were analytically verified at days 0, 7, 14, 21, 26 and 28. The analytical values show that the nominal concentrations of 0.1 and 0.01 mg/L were maintained at about 100% using SPAN 20, respectively. At days 0, 7, 14, 21, 26 and 28 two fish each were removed from each test group. Body weight was determined. The fish were homogenised and extracted. The extract was analysed with LC.
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.1 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: above limit of water solubility
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.1 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: above limit of water solubility
- Details on results:
- - Mortality of test organisms: no effects- Behavioural abnormalities:no effects- Observations on body length and weight:no effects- Other biological observations: no effects
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test material showed no toxic potential, the NOEC was > 0.1 mg/L.
- Executive summary:
Purpose
The purpose of this study was to determine the bioconcentration potential of the test material in fish under flow-through conditions. During the GLP compliant test the lethal and other effects in fish were determined during the exposure period of 28 days.
Study Design
The study was performed according to the OECD Guideline for Testing of Chemicals 305 (Bioconcentration: Flow-through Fish Test) adopted on June 14, 1996 using two test material concentrations for exposure to Cyprinus carpio. Two environmental concentrations of the test material of 0.1 and 0.01 mg/L were used in this study. SPAN 20 was used as vehicle at concentrations of 0.5 and 0.05 mg/L. The exposure was maintained during the couse of the study at about 100% of the nominal concentrations. The concentrations have been verified analytically using a LC method with UV detection.
Results
There was no mortality and no signs of toxicity detected throughout the study in any dose group up to 28 days of exposure.
Conclusion
The test material showed no relevant toxic potential at concentrations above the limit of water solubility.
Reference
Description of key information
For this endpoint data from a long term (28 d) bioconcentration study provide adequate information. This study has used SPAN 20 as vehicle to increase water solubility. In the long term 28 days study no mortality was observed up to 0.1 mg/L. Therefore the test material does not exhibit a significant potential for toxicity up the limit of water solubility.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.1 mg/L
Additional information
NOEC (BCF, 28d) > 0.1 mg/L (with SPAN 20 as solubiliser)
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