Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-003-3 | CAS number: 56519-71-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
NOAEL oral, systemic ≥1000 mg/kg bw/d (OECD 408)
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 2) from a reference substance with similar structure and intrinsic properties. Read-across is justified based on common functional group(s), common precursors and breakdown products and similarities in PC/ECO/TOX properties (refer to endpoint discussion for further details). The selected study is thus sufficient to fulfil the standard information requirements set out in Annex VIII-IX, 8.7, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for grouping of substances and read-across
There are no data available on the repeated dose toxicity of Propanediol dicaprylate (CAS 56519-71-2). In order to fulfill the standard information requirements set out in Annex VIII, 8.6, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from a structurally related substance was conducted.
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for human toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).
Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity.
Overview of repeated dose toxicity
CAS |
Chemical name |
Molecular weight |
Repeated dose toxicity oral |
56519-71-2 |
Propanediol dicaprylate |
328.49 |
RA: CAS 68583-51-7 |
68583-51-7 |
Decanoic acid, mixed diesters with octanoic acid and propylene glycol |
328.49 - 384.59 |
Experimental result: |
The above mentioned substances are considered to be similar on the basis of the structural similar properties and/or activities. The available endpoint information is used to predict the same endpoint for Propanediol dicaprylate (CAS 56519-71-2). A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
A repeated dose toxicity study is available which was conducted with the source substance Decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) in accordance with OECD guideline 408 and under GLP conditions in Wistar rats to assess the systemic toxicity at repeated doses. The substance was tested at dose levels of 0 (group 1), 100 (group 2), 300 (group 3) and 1000 (group 4) mg/kg bw/d. The test material was administered by gavage over a period of 90 days. 10 male and 10 female animals were used for each dose. In addition to the group 1 and the group 4, 5 male and 5 female animals were used to determine the reversibility of possible compound-related alterations (recovery group). All doses applied were tolerated without compound-related lethality. In each case 2 animals died earlier after the first respectively the second bloodletting. In the recovery group (1000 mg/kg bw/d), one male animal died after 35 applications without any substance related findings. No compound-related effects were observed. The mean food consumption of the male groups 2-4 showed some not dose-related variations. The mean food consumption of the female groups 2-4 showed a not dose-related decrease. The evident increase of the consumption in the group 4 in weeks 10, 12 and 13 of treatment was due to the high consumption of a single remaining animal in one cage. The mean water intake of the male groups 2-4 showed some no dose-related deviations. The mean water intake of the female groups 2-4 showed a not dose-related decrease. The evident increase of the consumption in the group 4 in weeks 10, 12 and 13 of treatment was due to reason mentioned above. The total body weight gain showed no compound-related deviations in all male and female test groups and was comparable to the controls.The haematological examinations showed no deviations in all male and female test groups. The clinical chemistry showed no deviations in all male and female test groups. The examination of the eyes by slit lamp microscope showed no compound-related effects. The absolute organ weights showed no deviations in all male and female test groups. The relative organ weights of the female group 2 showed an increase of the kidneys and a slight increase of the brain. The macroscopical examination of the organs of all groups, male and female, displayed some observations like hydrometra and edema in the area of the salivary glands which were noted as spontaneous. Possible compound-related effects were not observed. The organs of the male and female animals of the recovery group showed no macroscopical compound-related alterations after a treatment free period of 34 days. The microscopical examination of the organs of all male and female groups showed no compound-related effects, therefore no target organ was evaluated. Neither intermediate groups, nor the recovery groups were examined further. According to the study described, a daily administration of the test material up to 1000 mg/kg bw/d for male and female animals is not systemically toxic to rats. The NOAEL for this study is 1000 mg/kg bw/d.
Supportive information
The only functional group contained in the main product of 1,3-propanediol dicaprylate is the ester bond. Ester bonds are stable to acidic hydrolysis and so 1,3-propanediol dicaprylate is expected to enter the intestine unchanged. It is likely that lipases produced by the bile will initiate ester hydrolysis in the small intestine (Mattson, 1972). Any intact 1,3-propanediol dicaprylate ester that is absorbed will be rapidly cleaved by esterases in the blood (Testa, 2003). Main metabolites are expected to be 1,3-propanediol and caprylic acid. Since 1,3-propanediol caused no adverse effects upon oral administration for 90 days and caprylic acid is a naturally occurring fatty acid, subacute toxicity is not predicted for likely metabolites of propanediol dicaprylate.
Information on metabolites:
Subchronic oral toxicity study with 1,3-Propanediol (Gingell, 2003): NOEL = 1000 mg/kg bw
This study is published in a peer-reviewed journal by authors working for a chemical company or a contract research institute. Although not all details on the procedure are given, there is the general statement that the study was performed according the principles of Good Laboratory Practice and following the protocol given in the EPA Toxic Substances Control Act Health Effects Testing Guideline (40CFR 1989). Extensive hematological evaluations and sperm production/morphology were included because there were indications from in-vitro studies that malondialdehyde might be a metabolite. This study is therefore considered to be reliable and to give all relevant information on subchronic toxicity. Rats of the strain Crl:CD(SD)BR were treated by gavage with either 100, 300 or 1000 mg/kg bw of 1,3-propanediol for 90 days. Animals of the control group received water. For each dose group, 10 male and 10 female rats were used. The NOEL was determined to be 1000 mg/kg bw.
Caprylic acid occurs in food and is therefore part of the daily diet. In the USA, it has GRAS-status and is listed as a direct additive to food.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Hazard assessment is conducted by means of read-across from a structural analogue. The selected study is the most adequate and reliable study based on the identified similarities in structure and intrinsic properties between source and target substance and overall assessment of quality, duration and dose descriptor level (refer to the endpoint discussion for further details).
Justification for classification or non-classification
Based on read-across from a structurally related substance and following an analogue approach, the available data on the repeated dose toxicity do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.