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EC number: 605-937-4 | CAS number: 18162-75-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-07-12 to 2007-11-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- (92/69/EWG, C.3)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-(Morpholinomethyl)triethoxysilane
- IUPAC Name:
- N-(Morpholinomethyl)triethoxysilane
- Details on test material:
- - Name of test material (as cited in study report): Silan 44029 VP
- Substance type: pure active substance
- Physical state: liquid
- Stability under test conditions: pure: stable until 2007-08-07
in Water: rapid hydrolysis in water
- Storage condition of test material: room temperature in the dark
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- All concentrations in paralell and in duplicate at 0 and 72 h. Values available only for concentrations above LOQ
Test solutions
- Vehicle:
- no
- Details on test solutions:
- A Stock solution was prepared by dissolving 50 mg test item into 500 mL culture medium. The stock suspension was stirred for 24 hours in the dark to assure the hydrolysis of the test item. Adequat volumes of this test medium were diluted with culture medium to prepare the test media.
In the highest concentration of 32 mg/L the medium remain turbid over the complete 72 hours.
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Common name: Desmodesmus subspicatus (Chodat)
- Strain: No 86.81 SAG
- Source (laboratory, culture collection): University of Göttingen, Germany
- Method of cultivation: according to guidelines
ACCLIMATION
- 3 days
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Post exposure observation period:
- -
Test conditions
- Hardness:
- 24 mg CaCO3/L
- Test temperature:
- 23 °C
- pH:
- 8.0 at the beginning
8.1-8.6 at the end - Dissolved oxygen:
- not given
- Salinity:
- not given
- Nominal and measured concentrations:
- 0.32, 1, 3.2, 10, 32 mg/L nominal
At the start of the test just before introduction of the algae 82% of the nominal test concentrations were found. After 72 hours test duration 75% of th nominal values were determined. Thus, durin the test period of 72 hours the algae were exposed to a mean of 78% of nominal. Therefore, all reproted biological results are related to the initial mean concentraions of the test item. - Details on test conditions:
- TEST SYSTEM
- Test vessel: Erlenmeyer flasks of 50 mL volume with at least 30 mL of test medium
- Initial cells density: 5000 algal cells per mL
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
GROWTH MEDIUM
- Standard medium used: yes
TEST MEDIUM / WATER PARAMETERS
see above
OTHER TEST CONDITIONS
- Sterile test conditions: yes/no
- Adjustment of pH: no
- Photoperiod: continious
- Light intensity and quality: 6615 lux (mean)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: spectrophotometer
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: <100 mg/L
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate at least twice a year
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 7 mg/L
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- biomass
- Remarks on result:
- other: 6.6-7.4
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- growth rate
- Remarks on result:
- other: 22.0-29.1
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1.9
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- biomass
- Remarks on result:
- other: 1.7-2.1
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 6.6
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- growth rate
- Remarks on result:
- other: 4.6-8.4
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.8 mg/L
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.8 mg/L
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- biomass
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Observation of abnormalities (for algal test):
- Unusual cell shape: no
- Colour differences: not reported
- Flocculation: not reported
- Adherence to test vessels: not reported
- Aggregation of algal cells: not reported
- Any stimulation of growth found in any treatment: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: yes but considered, see above
- Effect concentrations exceeding solubility of substance in test medium: no - Results with reference substance (positive control):
- no details in report
- Reported statistics and error estimates:
- standard procedures
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 72-hours EC50 value was calculated to be 25.0 mg/L (NOEC: 0.8 mg/L) for the growth rate, and 7.0 mg/L (NOEC: 0.8 mg/L) for the biomass. Thus, it can be concluded that N-(Morpholinomethyl)triethoxysilan is toxic to the green algal species Desmodesmus subspicatus.
- Executive summary:
The infuence of N-(Morpholinomethyl)triethoxysilane on the growth of the freshwater green algal species Desmodesmus subspicatus was assessed in a static dose-response test (OECD Guideline 201). The 72-hours EC50 value was calculated to be 25.0 mg/L (NOEC: 0.8 mg/L) for the growth rate, and 7.0 mg/L (NOEC: 0.8 mg/L) for the biomass. Thus, it can be concluded that N-(Morpholinomethyl)-triethoxysilane is harmful to the green algal species Desmodesmus subspicatus.
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