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Diss Factsheets
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EC number: 700-421-6 | CAS number: 1215122-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
Classification according directive 2008/1272/EEC (CLP)
Classification according directive 2008/1272/EEC (CLP) is performed independently for acute and chronic hazards.
Actute hazard category:
The highest acute aquatic toxicity of three trophic levels was determined for the freshwater green alga Desmodesmus subspicatus with an EC50 (72 h; growth rate) for Read across susbtance C16 DMA of 9.9 µg/L. Due to the difficult substance properties of DMA the study was performed in natural river water. Sometimes mitigating effects are observed for river water tests compared to tests involving synthetic water. This was not the case for results on algal toxicity of DMA. Where reliable studies for both test types are available for comparison (C10 DMA, C16 DMA) effect concentrations observed in the river water test were even lower than those determined using synthetic dilution water. Therefore, a mitigating factor is not required. The algal EC50 (72 h; growth rate) to be used for classification is therefore 10 µg/L.
This results in the following acute classification:
Category Acute 1, H400: Very toxic to aquatic life
M-factor: 100
Chronic hazard category:
Using available acute data, decisive for a possible chronic classification is failure or fulfillment of (1) rapid degradability and / or (2) presence or absence of a bioaccumulation potential.
BCF fish were estimated using the Arnot & Gobas (2003) ADME model. The highest calculated value for the DMA Category members is 223 L/kg and this value is below the CLP criteria of 500. This means the DMAs are regarded as non-bioaccumulative.
Rapid biodegradability according to CLP is given for substances which were assessed as “readily biodegradable” in screening studies (OECD 301). This is met by DMA category members.
Under these circumstances, no chronic classification results for DMA category members from the available acute data on ecotoxicity.
Using available chronic data (algae, invertebrates): The lowest chronic (no) effect concentration of the two trophic levels with chronic data available was determined for the freshwater green algaDesmodesmus subspicatus: An EC10 (72 h; growth rate) of 2.56 µg/L was determined for C16 DMA. Due to the difficult substance properties of DMA category members the study was performed in natural river water. Sometimes mitigating effects are observed for river water tests compared to tests involving synthetic water. This was not the case for results on algal toxicity of DMA. Where reliable studies for both test types are available for comparison (C10 DMA, C16 DMA) effect concentrations observed in the river water test were even lower than those determined using synthetic dilution water. Therefore, a mitigating factor is not required. The algal EC10 (72 h, growth rate) to be used for classification is therefore 2.6 µg/L.
This results in the following chronic classification, taking into account ready biodegradability:
Category Chronic 1, H410: Very toxic to aquatic life with long lasting effects
M-factor: 1
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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