Registration Dossier
Registration Dossier
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EC number: 500-041-9 | CAS number: 25723-16-4 1 - 6.5 moles propoxylated
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
"Propylidyne trimethanol, propoxylated, 1-6.5 moles propoxylated is a relatively non-volatile liquid at room temperature (vapour pressure 0.002 Pa at 20ºC). The commercial material is soluble in water and has a log P of 0.5-1.6. There are no experimental studies on the toxicokinetics of propoxylated propylidyne trimethanol. The toxicokinetics of propoxylated propylidyne trimethanol are inferred from the toxicokinetics ‘read across’ to the core substance from pentaerythritol and nitrilotriethanol, and to repeating unit from propane-1,2-diol, oxydipropanol and [(methylethylene)bis(oxy)]dipropanol."
(cited from Illing, H P A, Barratt, M D (2007 revised 2009). Grouping of NLP ‘Polyols’ and their Toxicokinetics Assessments. Confidential report to the European Diisocyanate and Polyols Producers Association. December 2007, revised 2009.)
Discussion on bioaccumulation potential result:
"There are no experimental studies on the toxicokinetics of propoxylated propylidyne trimethanol. The toxicokinetics of propoxylated propylidyne trimethanol is inferred from the core substance and propane-1,2- diol, oxydipropanol and [(methylethylene)bis(oxy)]dipropanol. Propylidyne trimethanol has three free hydroxy groups, thus NLP polyols are likely to consist predominantly of chains of between one and two repeating units, with some chains containing three repeating units."
(cited from Illing, H P A, Barratt, M D (2007 revised 2009). Grouping of NLP ‘Polyols’ and their Toxicokinetics Assessments. Confidential report to the European Diisocyanate and Polyols Producers Association. December 2007, revised 2009.)
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