Pentanedioic acid, compd. with (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1:1)

Guidance on Safe Use

First-aid measures

Ingestion: Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.

Inhalation: Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing is difficult or ceases, ensure and maintain ventilation. Give oxygen as appropriate. The exposed subject should be kept warm and at rest. Obtain medical attention in cases of known or possible over exposure, or with symptoms including chest pain, difficulty breathing, loss of consciousness or other adverse effects, which may be delayed.

Skin Contact: Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which may be immediate or delayed.

Eye Contact: Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.

NOTES TO HEALTH PROFESSIONALS

* Medical Treatment: Because of the potential for acute or delayed eye damage, consider referral to an ophthalmologist. In allergic individuals, exposure to this material may require treatment for initial or delayed allergic symptoms and signs. This may include immediate and/or delayed treatment of anaphylactic reactions. Medical treatment in cases of overexposure should be treated as an overdose of an anti-viral agent. Treat according to locally accepted protocols. For additional guidance, refer to the local poison control information centre.

* Medical Conditions Caused or Aggravated by Exposure: This material may cause or aggravate allergy to any hazardous components. Ocular symptoms may be indicative of allergic reaction.

Health Surveillance Procedures: The need for pre-placement and periodic health surveillance must be determined by risk assessment. Following assessment, if the risk of exposure is considered significant then exposed individuals should receive health surveillance focused on detecting skin conditions. In the event of overexposure, individuals should receive post exposure health surveillance focused on detecting skin conditions and other allergy symptoms.

Antidotes: No specific antidotes are recommended.

Fire-fighting measures

Fire and Explosion Hazards: This material supports localised burning. Dust clouds are potentially highly sensitive to ignition from incendive

electrostatic discharges. Dust clouds are of low sensitivity to ignition from hot surfaces. No ignition or exotherm of a powder layer observed up to 400 °C. Ignition of a dust cloud produces a weak dust explosion. Moderate pressure between 6 and 8 bar is produced during a dust explosion.

Extinguishing Media: Water, dry powder or foam extinguishers are recommended. Carbon dioxide extinguishers may be ineffective.

Special Firefighting Procedures: Since toxic, corrosive or flammable vapours might be evolved from fires involving this material, self contained breathing apparatus and full protective equipment are recommended for firefighters. Move containers from the fire area if possible without increased personal risk. If possible, contain and collect firefighting water for later disposal.

Hazardous Combustion Products: Toxic, corrosive or flammable thermal decomposition products are expected when the material is exposed to fire.

Accidental release measures

Personal Precautions: For all spills, isolate the spill area, restrict access, post the area for a carcinogen and immediately implement emergency procedures for cleanup and control of occupational carcinogens. Wear protective clothing and equipment consistent with the degree of hazard. Avoid dust generation.

Environmental Precautions: Prevent entry into waterways, sewers, surface drainage systems and poorly ventilated areas. If spill is outdoors, cover with plastic sheet to minimise spreading or contact with rain.

Clean-up Methods: Collect and place it in a suitable, properly labelled container for recovery or disposal. After all solid or absorbent material has been collected, the area should be vacuumed with HEPA filter-equipped apparatus.

* Decontamination Procedures: No specific decontamination or detoxification procedures have been identified for this material. Consider use of water, detergent solutions, or other soluble solvents (if specified in Section 9 of this SDS), for clean-up and decontamination operations.

Handling and storage

Handling

General Requirements: Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended to provide routine control of fire and explosion hazards during handling of this material. Avoid dispersion as a dust cloud.

Ignition Controls: Any mechanical operations used for particle size reduction should be performed in a manner that do not produce localised heating. Bond and earth (ground) all plant and equipment to ensure that no isolated conductors are present. Isolated conductors can accumulate sufficient electrostatic charge to produce discharges of many hundreds of milli-Joules. Consider earthing (grounding) personnel dealing with dusty operations. An isolated (insulated) human body can readily produce electrostatic discharges in excess of 50 mJ, but have been recorded up to 100 mJ.

Minimise the use of plastics when handling this material. The maximum surface temperature of enclosures potentially exposed to this material should be the lower of the values obtained by taking 2/3 of the minimum ignition temperature for a dust cloud or 75 K less than the minimum ignition temperature of the dust layer, with a maximum temperature of 325°C.

Protective Systems: Assess operations based upon available dust explosion information to determine the suitability of preventive or protective systems as precautionary measures against possible dust explosions. If prevention is not possible, consider protection by use of containment, venting or

suppression of dust handling equipment. Where explosion venting is considered the most appropriate method of protection, vent areas should

preferably be calculated based on the Kst rather than the St value. If nitrogen purging is considered as the protective system, it must operate

with an oxygen level below the limiting oxygen concentration. The system should include an oxygen monitoring and shut-down facility in the event of

excessive oxygen being detected.

At both ambient and low humidity, this material is of low conductivity. Generation of electrostatic charge is considered likely to occur even when

handled in an earthed (grounded) environment.

At ambient humidity, this material has a long charge relaxation time. Accumulation of electrostatic charge is considered likely to occur even when handled in an earthed (grounded) environment. Under these conditions, it is considered that this material might present a very high risk of producing an electrostatic discharge.

At low humidity, this material has a very long charge relaxation time. Accumulation of electrostatic charge is considered very likely to occur even when handled in an earthed (grounded) environment. Under these conditions, it is considered that this material might present a very high risk of producing an electrostatic discharge.

Storage

Keep in tightly closed containers or packages away from moisture and away from sources of ignition. Avoid prolonged storage at elevated temperatures (greater than room temperature, approximately 20 degrees C).

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

Additional transport information

Additional information

Special provisions / remarks / other:

Avoid crushing the containers. In the event of a spillage, observe the warning labels on the container.

Exposure controls / personal protection

Occupational Exposure Limit: 600 mcg/m3 (8 HR TWA); CARCINOGEN, SKIN SENSITISER

Occupational Hygiene Air Monitoring Methods: An occupational/industrial hygiene monitoring method has been developed for this material. For advice on suitable monitoring methods, seek guidance from a qualified environment, health and safety professional.

ENGINEERING CONTROLS

* Exposure Controls: The hygiene guide for this material is >100 to 1000 mcg/m3. An Exposure Control Approach (ECA) is established for operations involving this material based upon the OEL/Occupational Hazard Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more information about how ECA's are assigned and how to interpret them.

Containment: Open handling should be limited to small quantities. Consider use of enclosures.

Ventilation: Local exhaust ventilation (LEV) should be applied at the source to capture contaminants from open or semi-enclosed operations.

Administrative: Entry to the working area should be controlled.

PERSONAL PROTECTIVE EQUIPMENT

* Eye Protection: Wear approved safety glasses with side shields or cover goggles if eye contact is possible.

Gloves: The selection of gloves for a specific activity must be based on the material's properties and on possible permeation and degradation that may occur under the circumstances of use. Glove selection must take into account any solvents and other hazards present. Potential allergic reactions can occur with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised if insufficient data are available and further guidance should be sought from your local EHS department.

* Respirators: If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air concentrations present, required protection factor as well as hazards, physical properties and warning properties of substances present.

* Other Equipment or Procedures: Follow all local regulations if personal protective equipment (PPE) is used in the workplace. Wear appropriate clothing to avoid skin contact. An eye wash station should be available.

Stability and reactivity

Thermal Stability: Thermal hazard screening indicated that the rate of self-heating and energy of decomposition are unlikely to present a hazard. Further tests should be considered if the proposed processing or drying temperature is above 150°C.

Conditions to Avoid: Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud.

Disposal considerations

Disposal Recommendations: Collect for recycling or recovery if possible. The recommended method of disposal is incineration. Wherever possible, disposal should be in an on-site licenced chemical incinerator, if allowed by the incinerator licence or permit. If no on-site incinerator is available, dispose of material in a licenced commercial chemical incinerator.

Regulatory Requirements: Observe all local and national regulations when disposing of this material.