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EC number: 413-010-9 | CAS number: 6613-44-1 DMBC
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The report does not contain the full details of the toxicological study.
Data source
Reference
- Reference Type:
- other: Health-Environmental Adverse Effect Report (HEAR)
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
- Principles of method if other than guideline:
- This report details the neurotoxic effects noted in the acute oral study summarised in Section 7.2.1, report number 92R-102.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,5-dimethylbenzoyl chloride
- EC Number:
- 413-010-9
- EC Name:
- 3,5-dimethylbenzoyl chloride
- Cas Number:
- 6613-44-1
- Molecular formula:
- C9H9ClO
- IUPAC Name:
- 3,5-dimethylbenzoyl chloride
- Details on test material:
- DMBC
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CDBR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- Single dose
- Frequency of treatment:
- Single dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500, 2000 and 5000 mg/kg bw.
Basis:
actual ingested
- No. of animals per sex per dose:
- 6 per sex per dose
- Control animals:
- no
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- All female rats in the 5000 mg/kg group subsequently died. Signs of neurotoxicity were seen.
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- All female rats in the 5000 mg/kg group subsequently died. Signs of neurotoxicity were seen.
- Details on results:
- Clinical signs indicative of neurotoxic effects (tremors, hyperreflexia, twitching of extremities and convulsions (i.e., opisthotonos)) were observed in female rats after a single oral dose of DMBC in corn oil at 5000 mg/kg (10 mL/kg). All female rats in the 5000 mg/kg group subsequently died. One male rat in the 5000 mg/kg group showed tremors; however, this animal survived. No other males showed neurotoxic signs.
Effect levels
open allclose all
- Dose descriptor:
- other: LD50
- Effect level:
- > 2 000 - < 5 000 mg/kg bw/day
- Sex:
- female
- Remarks on result:
- other:
- Dose descriptor:
- other: LD50
- Effect level:
- > 5 000 mg/kg bw/day
- Sex:
- male
- Remarks on result:
- other:
Applicant's summary and conclusion
- Conclusions:
- DMBC showed neurotoxic effects in an acute oral study conducted in rats.
- Executive summary:
Clinical signs indicative of neurotoxic effects (tremors, hyperreflexia, twitching of extremities and convulsions (i.e., opisthotonos)) were observed in female rats after a single oral dose of DMBC in corn oil at 5000 mg/kg (10 mL/kg). All female rats in the 5000 mg/kg group subsequently died. One male rat in the 5000 mg/kg group showed tremors; however, this animal survived. No other males showed neurotoxic signs.
The oral LD50 was between 2000 and 5000 mg/kg in females and greater than 5000 mg/kg in males. No clinical signs indicative of neurotoxicity were observed at doses of 2000 mg/kg or less in either sex.
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