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EC number: 275-118-0 | CAS number: 71010-76-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
Findings from a chronic sediment OECD 225 study showed that the registered substance did not cause any long-term effects on mortality, growth (biomass) or reproduction (number of live worms) in the benthic sediment blackworm, Lumbriculus variegatus, after 28 days of exposure in sediment at 102 mg/kg (limit test). The 28-day NOELR was ≥ 102 mg/kg soil d.w. based on no effects on mortality, growth and reproduction. The registered substance is not expected to cause any long-term toxicity or adverse effects to organisms in the sediment or terrestrial compartments. No PNEC for sediment could be derived for quantitative risk assessment. However, it is possible to qualitatively conclude that the registered substance does not pose an unacceptable risk to sediment-dwelling organisms. .
Key value for chemical safety assessment
Additional information
After 28 days of exposure, there were no statistically significant treatment-related effects on the reproductive output (number of live worms) or growth (e.g., biomass - dry weight) when the treatment group was compared to the control (p= 0.05). As such, the 28-day NOELR for both reproduction and growth is equal to or greater than the limit loading concentration tested (102 mg/kg). The 28-day EL50 (reproduction, growth) is expected or can be deduced to be greater than 102 mg/kg since no differences were observed between the control and treated groups.
In conclusion, the findings from this chronic OECD 225 toxicity test indicate that the registered substance did not cause any long term effect on mortality, growth (biomass) or reproduction (i.e., number of live worms) in the benthic Lumbriculus variegatus after 28 days of exposure in sediment. In addition, no behavioral effects were observed in the blackworms when the treatment group was compared with the control group.
The following information is taken into account for sediment toxicity for the derivation of PNEC:
Results from a 28-day chronic sediment study clearly indicate that the registered substance is not expected to cause any long term effects on sediment organisms likeLumbriculus variegatus. The 28-day NOELR ≥ 102 mg/kg soil d.w. based on no effects on mortality, growth and reproduction.
Besides not causing any long-term effects on sediment organisms, the registered substance showed no long-term adverse effects to soil microorganisms in a 28-day OECD 216 nitrogen transformation test (Carter, 2014). Futhermore, the registered substance did not have any long-term effects on terrestrial earthworm reproduction and growth in a 56-day OECD 222 test (Kelley 2014) and did not have any acute mortality to earthworms in a 14-day OECD 207 acute toxicity test (Kelley 2013). Lastly, the registered substance did not have any long-term effects on the seedling emergence, growth and reproduction of two terrestrial plants,B. rapaandA. sativain 35-day and 52-day ISO 22030 chronic plant toxicity tests, respectively (Butler, 2014). Collectively, these findings as well as the previously discussed lack of acute and chronic aquatic toxicity provide further support that the registered substance, CAS 71010-76-9), is not likely to pose a concern to sediment dwelling organisms. The lack of sediment toxicity is probably attributable to the low water solubility, high log Kow (inability to cross biomembrane) and low bioavailability of the registered substance. In addition, the registered substance is readily biodegradable, rapidly metabolized and it is not persistent or bioaccumulative.
As no PNEC for water could be determined (no aquatic toxicity),it is not possible to derive a PNEC for sediment using the EqPM (equilibrium partitioning method). The available chronic toxicity data inLumbrulus variegatusindicate that the registered substance is not expected to cause any adverse effects to sediment. While it is not possible to derive PNECs needed for quantitative risk assessment, it is possible to qualitatively conclude based on the available sediment toxicity data above as well as related terrestrial test data that the registered substance does not pose an unacceptable risk in sediment-dwelling organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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