Registration Dossier
Registration Dossier
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EC number: 256-905-8 | CAS number: 51000-52-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The Klimisch 1 acute 72 hr algal study in 2000 conducted according to O.E.C.D. Testing Guideline 201 with GLP compliance and test substance concetration analytical determination is the most appropriate and reliable study on which to base an algal PNEC. The EC50 value for this study was 3.4 mg.L and the NOEC for this study was 0.42 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 3.4 mg/L
Additional information
ECHA guidance (RIP 3.2, Chapter R. 10) suggests applying a 1000-fold Assessment Factor to an acute freshwater EC50 value to derive the PNEC. Therefore that freshwater algal PNEC is 3.4 (mg/L)/1000 = 3.4 ug/L. To derive a marine algal PNEC from freshwater algae study data, ECHA guidance recommends an Assessment Factor of 10,000-fold. Therefore, the marine algal PNEC based on the freshwater algal EC50 value of 3.4 mg/L 0.34 ug/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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