Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 249-828-6 | CAS number: 29761-21-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The key study was a human Repeated Insult Patch Test. The study has a proper design and results are reported well. This test was performed on the skin of 50 human volunteers (21 males and 29 females). 15 induction exposures were applied, 3 times/week, for 24 hours. After 14 days of no contact with the test material, 1 challenge exposure was applied for 24 hours. Evaluation after challenge occurred at 0, 24 and 48 hours after removal of the patch. Under the conditions of this study, IDDPP was found not to induce any positive reaction in human skin after challenge.
A Two Application Patch Test was available as a supporting study. 100 males and 100 female volunteer subjects were exposed twice to IDDPP (15 days rest period between treatments) for 48 hours on the upper arm using an occluded patch (impregnated paper). Skin reactions were scored at 0, 24 and 48 hours after removal of the patch to determine the sensitising potential of the test substance. Under the conditions of this study, IDDPP was found not to induce any positive reaction in human skin after challenge.
Migrated from Short description of key information:
Human Repeated Insult Patch Test (no guideline available): not sensitising.
Justification for classification or non-classification
Based on the results of both skin sensitisation studies IDDPP does not need to be classified as a skin sensitiser when considering the criteria outlined in Annex I of 1272/2008/EC and Annex VI of 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
