Registration Dossier
Registration Dossier
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EC number: 240-969-9 | CAS number: 16919-27-0
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Recent review of published work on fluoride ions.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The EU RAR summarises the results of a number of relevant studies
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Details on sampling:
- No details of sampling given in review.
- Vehicle:
- no
- Details on preparation and application of test substrate:
- No details on preparation and application of test substance given in the review.
- Test organisms (inoculum):
- soil
- Total exposure duration:
- 63 d
- Test temperature:
- Not stated
- Moisture:
- Not stated.
- Details on test conditions:
- No further details given in review
- Nominal and measured concentrations:
- not stated
- Reference substance (positive control):
- no
- Duration:
- 24 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Dehydrogenase inhibition
- Remarks on result:
- other: sodium fluoride
- Duration:
- 63 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 340 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: NH4-minerilisation
- Remarks on result:
- other: potassium fluoride
- Duration:
- 63 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 106 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: NO3-mineralisation
- Remarks on result:
- other: potassium fluoride
- Duration:
- 63 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 060 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: P-mineralisation
- Remarks on result:
- other: potassium fluoride
- Details on results:
- The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive in the micro-ecosystem test.
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Not applicable
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 d experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive in the micro-ecosystem test.
- Executive summary:
The EU RAR reports NOEC values from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber. Nitrification was found to be the most sensitive endpoint investigated in the micro-ecosystem test.
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Dipotassium hexafluorotitanate is an inorganic substance which will rapidly dissociate into fluoride, potassium and titanium ions upon dissolution in the environment. However, titanium ions do not remain in solution, only fluoride ions do.
The approach follows scenario 1 of the RAAF (ECHA 2017).
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source
sodium fluoride (CAS 7681-49-4)
potassium fluoride (CAS 7789-23-3)
Target
Dipotassium hexafluorotitanate (CAS 1619-27-0)
3. ANALOGUE APPROACH JUSTIFICATION
Since dipotassium hexafluorotitanate rapidly dissociates into fluoride, potassium and titanium ions upon dissolution in the environment, and only fluoride but not titanium ions will remain in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, the lowest available NOEC of 106 mg F/kg for the long-term toxicity (63 days) of potassium fluoride to NO3-mineralisation (nitrification) is read-across to dipotassium hexafluorotitanate resulting in a NOEC of 223.3 mg/kg.
4. DATA MATRIX
see attached read-across statement in section 13.2 - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 24 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Dehydrogenase inhibition
- Remarks on result:
- other: sodium fluoride
- Duration:
- 63 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 340 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: NH4-minerilisation
- Remarks on result:
- other: potassium fluoride
- Duration:
- 63 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 106 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: NO3-mineralisation
- Remarks on result:
- other: potassium fluoride
- Duration:
- 63 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 060 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: P-mineralisation
- Remarks on result:
- other: potassium fluoride
- Details on results:
- The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive in the micro-ecosystem test.
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Not applicable
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 d experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive in the micro-ecosystem test.
- Executive summary:
The EU RAR reports NOEC values from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber. Nitrification was found to be the most sensitive endpoint investigated in the micro-ecosystem test.
Referenceopen allclose all
The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 d experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber. Nitrification was found to be the most sensitive in the micro-ecosystem test.
The NOEC values detailed in the report range from 106 to 3000 mg/kg. The 63 d experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber. Nitrification was found to be the most sensitive in the micro-ecosystem test.
Description of key information
Since dipotassium hexafluorotitanate rapidly dissociates into fluoride, potassium and titanium ions upon dissolution in the environment, and only fluoride but not titanium ions will remain in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, the lowest available NOEC of 106 mg F/kg for the long-term toxicity (63 days) of potassium fluoride to NO3-mineralisation (nitrification) is read-across to dipotassium hexafluorotitanate resulting in a NOEC of 223.3 mg/kg.
Key value for chemical safety assessment
- Long-term EC10 or NOEC for soil microorganisms:
- 223.3 mg/kg soil dw
Additional information
Dipotassium hexafluorotitanate
Since dipotassium hexafluorotitanate rapidly dissociates into fluoride, potassium and titanium ions upon dissolution in the environment, and only fluoride but not titanium ions will remain in solution,it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across of soil microbial toxicity data of potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion is justified (see below).
Fluorides
The EU RAR reports NOEC values from 106 to 3000 mg/kg. The 63 day experiments were carried out in a micro-ecosystem containing poplar litter (30% o.m) and the isopod Porcellio scaber Latr. Nitrification was found to be the most sensitive endpoint investigated in the micro-ecosystem test.
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