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EC number: 238-475-3 | CAS number: 14481-26-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Dipotassium titanium oxide dioxalate
- EC Number:
- 238-475-3
- EC Name:
- Dipotassium titanium oxide dioxalate
- Cas Number:
- 14481-26-6
- Molecular formula:
- C4K2O9Ti
- IUPAC Name:
- dipotassium oxotitaniumbis(ylium) dioxalate
Constituent 1
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Remarks on result:
- not determinable because of methodological limitations
- Details on results:
- The partition coefficient (n-octanol/water) of the test item was estimated by performing the OECD
guideline 117. No information was available on the dissociation coefficient of the test item. So in a first
time, the HPLC method was applied with 6 reference items on C18 column eluated with water / Methanol
(45/55) without buffer.
In these conditions, the retention time of the test item was observed in the dead time. So the Log Pow
of the test item was estimated < 0. Consequentially, the Log Pow estimated was not in the applicability
range of the method (0 to 6) as described in the OECD guideline 117 § 4.
In addition, this result may suppose that the test item was dissociated in the mobile phase used.
Thus, additional tests on the solubility of the test item was carried out with mobile phase buffered in acid
and basic conditions.
These tests shown that the test item is soluble in the mobile phase at pH 2 but not soluble in the mobile
phase buffered at pH 9 (probably in their non-ionised form).
To conclude, the test OECD 117 is not applicable on the test item in their non-ionised form and can not
be performed.
Applicant's summary and conclusion
- Conclusions:
- The Log Pow of the test item was estimated < 0 so it is not in the applicability range 0 to 6 of the OECD
guideline 117 (§ 4 of the guideline). This result may suppose that the test item was dissociated in the
mobile phase used (Ultra-pure water / Methanol (45/55) without buffer).
No information was available on the dissociation coefficient of the test item, so additional tests on the
solubility was carried out with acid and basic buffer in order to performed the OECD 117 with the test
item in their non-ionised form. As recommended in the OECD guideline § 9.
The solubility tests (figure 1) shown that the test item is not soluble in the mobile phase buffered at pH
9 (probably in their non-ionised form).
To conclude, the test OECD 117 is not applicable on the test item in their non-ionised form and can not
be performed.
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