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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
OECD guideline study, published in literature, minor restrictions in reporting, but otherwise adequate for assessment.
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
yes
Remarks:
Slight modifications
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Details on test conditions:
TEST SYSTEM
The stock solutions were prepared fresh each day. The test solutions were renewed daily.

TEST MEDIUM / WATER PARAMETERS
- Detailed information about the chemical composition of the media is given elsewhere (Van Leeuwen and Maas, 1985).
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
0.24 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 95% CL: 0.20-0.29

Description of key information

The 48-h EC50 of 0.24 mg/L in Daphnia magna is used in the assessment. 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.24 mg/L

Additional information

Two short-term toxicity studies with Daphnia magna are available for zinc diethyldithiocarbamate. A non-GLP, OECD 202 guideline study is available (van Leeuwen et al., 1985a; van Leeuwen, 1986). The test is semi-static without analytical monitoring. The 48-h EC50 value is 0.24 mg/L in Daphnia magna.

 

Another study is a static GLP-compliant, EPA-660/3-75-009 guideline study without analytical monitoring (Analytical Bio-Chemistry Laboratories, Inc., 1983d). The 48-h EC50 value in Daphnia magna is 0.44 mg/L.

The 48-h EC50 of 0.24 mg/L is the most critical value and is therefore used for assessment.