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Diss Factsheets
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EC number: 233-237-5 | CAS number: 10099-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to aquatic plants other than algae
Administrative data
- Endpoint:
- toxicity to aquatic plants other than algae
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
- Principles of method if other than guideline:
- La kinetics were studied in duckweed with different exposure regimes: 1. La uptake from refreshed medium, 2. La uptake from non-refreshed medium, 3. La uptake from non-refreshed medium and elimination in refreshed medium.
- GLP compliance:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): Lanthanum
- Molecular formula (if other than submission substance): La Cl3*7(H2O)
- CAS No.: 10025-84-0
- Analytical purity: 99.999%
- Lanthanum was spiked with the radionuclide 140La (t1/2 = 40.3 h), which emits beta and gamma radiation. (Main E(gamma) are 329, 487,
816, and 1,596 keV).
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Lanthanum was spiked with the radionuclide 140La (t1/2 = 40.3 h), which emits beta and gamma radiation. 140La was prepared by irradiating a quartz vial containing a solution of 0.1 mM LaCl3.7H2O in Milli-Q water at a neutron flux of 1.60 X 10E17/(m2·s) for 24 h in the Hoger Onderwijs Reactor of the institute. The solution was allowed to decay for 3 h to eliminate the short-lived chloride isotope 38Cl (t1/2 = 37.2 min) and was subsequently added to the rest of the medium components to make up a final La concentration of 10 nM.
Test organisms
- Test organisms (species):
- Lemna minor
- Details on test organisms:
- no data available
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 192 h
- Remarks on exposure duration:
- 1. exp.: 192 h; 2. exp.: 167 h, 3. exp.: 169 h
Test conditions
- Hardness:
- no data
- Test temperature:
- 25 +/- 28°C
- pH:
- initial pH of 5.05 +/- 0.05
- Dissolved oxygen:
- no data
- Nominal and measured concentrations:
- 10 nmol/L
- Details on test conditions:
- Plants were cultured axenically and exposed in a climate chamber at a light intensity of 10,000 lux and a day:night regime of 16:8 h. Relative humidity was approximately 70% and the temperature 25 +/- 28°C. The exposure substrate was a sterilized low-level nutrient medium, adapted from the Swedish Standards Institute (SIS), with an initial pH of 5.05 +/- 0.05.
Plants were exposed in 200 mL medium in glass vessels, which were closed with a glass lid to minimize evaporation but allow limited gas exchange. Plant fresh weight was determined after spin drying at 3,000 rpm for 10 min at room temperature to remove attached and free-space water.
1. Exp: Twenty glass vessels with medium and 10 nM La and 20 glass vessels with La-free medium were inoculated with 12 duckweed fronds (3–5 colonies). Plants in vessels without La served as a control group to compare their growth rate with La-exposed plants and study possible toxicity or growth stimulation of La. At times 48, 96, 144, and 192 h, plants were transferred to vessels with fresh medium (with or without La). At times 0, 4, 8, 24, 45, 55, 72, 94, 124, 168, and 216 h, the pH of the medium was measured, fresh weight was determined, and La concentrations in media and plants and La amounts on lass vessels were measured.
2. Exp.:Twenty-seven glass vessels with medium and 10 nM La were inoculated with 12 duckweed fronds (3–5 colonies). In addition, three vessels with medium but no plants were followed in time to check for possible precipitation and constancy of pH. The first 48 h were thus the same as for experiment 1. At times 0, 1, 3, 5, 24, 48, 92, 120, and 167 h, pH of the media was measured, plant fresh weight was determined, and La concentrations in media and plants and La amounts on glass vessels were measured. All measurements were performed in triplicate.
3. Exp.: Twenty-eight glass vessels with medium and 10 nM La were inoculated with 12 duckweed fronds (3–5 colonies). In addition, three vessels with medium but no plants were followed in time to check for possible precipitation and constancy of pH. The first 48 h were the same as for experiments 1 and 2. To study elimination, plants from 15 vessels were gently lifted off the surface after 48 h of accumulation and transferred, without spin drying, to vessels with La-free medium. This medium was refreshed at times 55, 72, 120, and 144 h to keep the La concentration in medium as low as possible and thus prevent backflow of La to plants. At times 0, 5.5, 12, 24, 48, 55, 72, 96, 144, and 169 h, pH of the media was measured, fresh weight was determined, and La concentrations in media and plants and La amounts on glass vessels were measured. Measurements were performed in duplicate (accumulation) or triplicate (elimination). - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 196 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.01 µmol/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Test substance: Lanthanum trichloride heptahydrate
- Duration:
- 196 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 3.71 µg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Test substance: Lanthanum trichloride heptahydrate
- Duration:
- 196 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 2.45 µg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Test substance: lanthanum trichloride anhydrous
- Details on results:
- During the course of the experiments, duckweed growth was purely exponential, indicating that growth limitation under the present conditions is not occurring. The associated maximum concentration of La in L. minor without effects was 12 nmol/g fresh weight.
Any other information on results incl. tables
The authors stated that L. minor takes up La from medium as LaEDTA2 complex and/or as ionic La3+, reaching a BCFdyn of 32,970 L/kg on a dry weight basis. Elimination study revealed a large (60%) slow and small (40%) fast compartment. The large compartment eliminates mainly by means of maintaining a high growth rate. The proposed model incorporating a mass balance rule and exponential growth of the exposed organism agreed well with the experimental data. Neither stimulating nor toxic effects of 10 nM complexed La on duckweed growth in 9 d were observed. However, considering the high BCFdyn values, effects may occur under constant exposure as uptake continues at the rate reported here.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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