Registration Dossier
Registration Dossier
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EC number: 233-071-3 | CAS number: 10028-18-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Many high quality studies are available in the database of acute toxicity to fish. A lumped data set for nickel-based compounds was considered for endpoint coverage. The lowest 96h-LC50 was 0.23 mg Ni/L for freshwater fish and 24.8 mg Ni/L for marine fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 0.23 mg/L
Marine water fish
Marine water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 24.8 mg/L
Additional information
Effect of Nickel in solution - Fresh water
From the database of acute toxicity to freshwater fish, there are many high quality studies. This represents different freshwater fish species, dominated by Pimephales promelas, Oncorhynchus mykiss, and Cyprinus carpio. The 96h LC50s values range from 0.23 mg Ni/L (Pimphales promelas; Hoang et al., 2004) to 320 mg Ni/L (Brachydanio rerio; NiPERA, 1993).
Effect of Fluoride in solution - Fresh water
Fluoride effect on fresh water fish was measured as worst case at LC50 = 51 mg/L fluoride ion, 96 h exposure. This value is much above the risk caused by dissolved Ni2+. The contribution from fluoride ion is therefore considered to be totally negligible.
CONCLUSIONS: LC50 0.23 mg/L Ni (= LC50 0.38 mg/L NiF2 anhydrous)
Effect of Nickel in solution - Marine water
From the database of acute toxicity to marine fish, there are several high quality studies, representing different marine fish species. The 96h LC50s values range from 24.8 mg Ni/L (Fundulus heteroclitus; Bielmyer et al., 2013) to 350 mg Ni/L (Fundulus heteroclitus; Eisler and Hennekey, 1977).
Effect of Fluoride in solution - Marine water
Fluoride effect on marine water fish was measured as worst case at LC50 > 500mg/L, 96 h exposure. This value is much above the risk caused by dissolved Ni2+. The contribution from fluoride ion is therefore considered to be totally negligible.
CONCLUSIONS: LC50 24.8 mg/L Ni (= LC50 40.9 mg/L NiF2 anhydrous)
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