Registration Dossier
Registration Dossier
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EC number: 226-844-1 | CAS number: 5504-92-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25.05.-11.08.2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
Test material
- Reference substance name:
- 2-bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide
- EC Number:
- 226-844-1
- EC Name:
- 2-bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide
- Cas Number:
- 5504-92-7
- Molecular formula:
- C15H10BrCl2NO2
- IUPAC Name:
- 2-bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- < 0.05 mg/L
- Temp.:
- 20 °C
- pH:
- >= 7.8 - <= 8.5
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The column elution method was used for the determination of the water solubility. The mean
flow rate for the 1st run was 36 ml h-1 and for the 2nd run 18 ml h-1. The resulting eluate
fractions were collected and analyzed by HPLC with UV detection.
According to the calibration curve of the test item the water solubility of BDB can be
estimated smaller than 0.05 mg l-1 at 20 °C.
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